We have 53 University of Dundee, Faculty of Life Sciences PhD Projects, Programmes & Scholarships

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University of Dundee, Faculty of Life Sciences PhD Projects, Programmes & Scholarships

We have 53 University of Dundee, Faculty of Life Sciences PhD Projects, Programmes & Scholarships

MSc by Research: Investigating the Natural Variation of Ubiquitin-Like-Proteins Across the Eukaryotic Tree of Life

University of Dundee

Faculty of Life Sciences

Ubiquitin and Ubiquitin-Like-Proteins are highly conserved across the eukaryotic tree of life. They regulate a wide range of cellular processes via the ubiquitin-proteasome pathway, whereby ubiquitin is covalently bonded to a target protein. Read more

Supervisor: Dr H Drost

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: How are SUMO substrates selected for modification

University of Dundee

Faculty of Life Sciences

SUMO has diverse roles in cellular physiology that in most cases are mediated by its ability to interact non-covalently with hydrophobic patches of low sequence complexity known as SUMO Interaction Motifs (SIMs). Read more

Supervisor: Prof R Hay

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Molecular mechanisms underlying aphid effector virulence activity

University of Dundee

Faculty of Life Sciences

Pests and diseases are a major threat to food security with losses ranging between 20-40%. Aphids are one of the most devastating insect pests, globally. Read more

Supervisor: Dr J Bos

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Molecular Glues for ALS: Restoring TDP-43 Localization for drug discovery

University of Dundee

Faculty of Life Sciences

Proteins rarely function in isolation; instead, they form biomolecular complexes by interacting with other biomolecules, including DNA, RNA, and proteins. Read more

Supervisors: Dr P Cossar, Dr L McGurk

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Designing Molecular Glue Stabilizers to Restore Tumour Suppressor Function

University of Dundee

Faculty of Life Sciences

Molecular glues, small molecules that facilitate the assembly of biomolecular complexes, have emerged as a transformative drug discovery strategy for treating diseases such as cancer and neurodegeneration. Read more

Supervisor: Dr P Cossar

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Defying Mendel’s laws: developing tools to understand the principles of epigenetic inheritance in tomato plants

University of Dundee

Faculty of Life Sciences

In plants, phenotypic innovation is not exclusively encoded in DNA sequences. Some heritable new traits are associated with modifications on the DNA, such as DNA methylation. Read more

Supervisor: Dr C Martinho

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Cell migration in epithelial tissues

University of Dundee

Faculty of Life Sciences

It is an important question to answer how cells move in a crowded environment. In this project, we’ll use the vertex model (a widely used computational framework for cell-based studies of epithelial tissue mechanics) to study motion of a small patch of motile cells in otherwise inert environment. . Read more

Supervisor: Dr R Sknepnek

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Deciphering the ubiquitin codes that regulate protein degradation

University of Dundee

Faculty of Life Sciences

Ubiquitin signalling, which involves the posttranslational modification (PTM) of proteins with ubiquitin, regulates almost every aspect of eukaryotic biology. Read more

Supervisor: Prof Y Kulathu

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Mechanisms of cell size regulation

University of Dundee

Faculty of Life Sciences

The tremendous diversity of cell shapes and sizes found in living organisms is fascinating. For instance, cell size differs enormously in the human body with myocytes being about a million-fold larger than red blood cells. Read more

Supervisors: Dr J Januschke, Dr D H Murray

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Heart failure and fatal epilepsy caused by unbranched glycogen

University of Dundee

Faculty of Life Sciences

The accumulation and precipitation of unbranched glycogen in human tissues as toxic polyglucosan bodies (PB) is the cause of cardiomyopathy… Read more

Supervisors: Prof Sir Philip Cohen, Dr K Swatek

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Greasing plant cell signalling – the role of S-acylation in plant receptor cytoplasmic kinase signalling during immune responses

University of Dundee

Faculty of Life Sciences

Protein S-acylation is a reversible fatty acid-based post-translational modification of proteins. Read more

Supervisors: Dr P Hemsley, Dr J Bos

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Reporting on destruction – developing plant-based assays for PROTAC degrader activity

University of Dundee

Faculty of Life Sciences

Protein Targeting Chimera (PROTAC) degraders are small molecules able to recruit a ubiquitin ligase to a protein of interest and promote degradation. Read more

Supervisors: Dr P Hemsley, Prof A Ciulli, Dr H Drost

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Trimming the fat - Identification of de-S-acylating enzymes from plants

University of Dundee

Faculty of Life Sciences

Protein S-acylation is a reversible fatty acid-based post-translational modification of proteins. Read more

Supervisors: Dr P Hemsley, Dr J Bos

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Role and mechanism of the bacterial Type VI secretion system

University of Dundee

Faculty of Life Sciences

Many species of bacteria use a contractile nanomachine known as the Type VI secretion system (T6SS) to deliver a wide range of toxic proteins, known as ‘effectors’, directly into neighbouring cells. Read more

Supervisor: Dr S Coulthurst

Year round applications PhD Research Project Self-Funded PhD Students Only

MSc by Research: Identifying microbiota responsible for longevity and health

University of Dundee

Faculty of Life Sciences

Gut microbiome is the community of microbes living together in the gastrointestinal tract of an animal. They provide specific functions to the animal host such as digestion of cellulose and protection from invading pathogens. Read more

Supervisor: Dr V Singh

Year round applications PhD Research Project Self-Funded PhD Students Only

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