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We have 13 University of Sheffield, School of Medicine and Population Health PhD Projects, Programmes & Scholarships

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University of Sheffield, School of Medicine and Population Health PhD Projects, Programmes & Scholarships

We have 13 University of Sheffield, School of Medicine and Population Health PhD Projects, Programmes & Scholarships

University of Sheffield

Our University has a reputation for world-class teaching and research excellence across a variety of disciplines

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Targeting dormant cancer cells in myeloma

University of Sheffield School of Medicine and Population Health
Multiple myeloma is the second most common blood cancer and remains essentially incurable. Chemotherapy is effective at reducing tumour and extends survival, but it never fully eradicates disease, so patients face inevitable relapse. Read more
 Supervisors: Dr A Green, Prof S El-Khamisy
 31 May 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Unravelling the role of P4HB in skeletal development: towards treatment of heritable bone fragility

University of Sheffield School of Medicine and Population Health
Osteogenesis Imperfecta (OI) affects 1 in 15-20,000 live births and results in a childhood with frequent fractures, reduced mobility and joint problems. Read more
 Supervisor: Dr M Balasubramanian
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Precision Therapy for NBAS-related disorder

University of Sheffield School of Medicine and Population Health
It is very well recognised that rare diseases offer the potential to uncover new information about mechanisms underlying a range of phenotypes. Read more
 Supervisor: Dr M Balasubramanian
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Mining data from National genomics Research Library to enable new gene discovery

University of Sheffield School of Medicine and Population Health
Whole Genome Sequencing (WGS) is a new genomic testing technology and process which became available through the NHS in April 2022. Read more
 Supervisor: Dr M Balasubramanian
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using genome sequencing to find the cause of undiagnosed rare conditions affecting bowel, heart, lung or brain in adults

University of Sheffield School of Medicine and Population Health
In the UK, a rare condition is one that affects fewer than 1/2000 people. Around 70% of rare conditions have a genetic cause (ie are caused by a change… Read more
 Supervisor: Dr A McNeill
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Developing a guideline for predictive genetic testing in motor neuron disease (MND)

University of Sheffield School of Medicine and Population Health
Motor neuron disease (MND) is an incurable neurological condition which causes weakness, swallowing difficulties and shortness of breath. In some people… Read more
 Supervisor: Dr A McNeill
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Developing a clinical pathway to support nurse led whole genome sequencing for neurological diseases

University of Sheffield School of Medicine and Population Health
In this project we will develop pathways to enable specialist nurses to request whole genome sequencing (WGS) for adult neurology patients throughout the NHS; improving the efficiency of the process, freeing consultant neurologist time and improving equity of access. Read more
 Supervisor: Dr A McNeill
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of a Long Acting Parathyroid Hormone Fusion for the Treatment of Hypoparathyroidism

University of Sheffield School of Medicine and Population Health
Background. Parathyroid hormone (PTH) is an 84 aa peptide produced by the parathyroid glands and is responsible for calcium homeostasis. Read more
 Supervisors: Dr I Wilkinson, Prof J Newell-Price
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Finding the cause of familial facial (Bell’s) palsy

University of Sheffield School of Medicine and Population Health
The facial (VII) cranial nerve controls the muscles of facial expression, supplies taste sensation to parts of the tongue and controls a small muscle connected to the ear drum. Bell’s palsy is the clinical condition in which there is impaired function of the facial nerve, associated with facial muscle weakness. Read more
 Supervisor: Dr A McNeill
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring Uncharted Territories: Investigating the Impact of Follicular Fluid Extracellular Vesicles on Spermatozoa Function

University of Sheffield School of Medicine and Population Health
The intricate dynamics underlying successful mammalian reproduction continue to captivate scientific inquiry. However, the mechanisms governing the interaction between spermatozoa and the female reproductive tract remain elusive. Read more
 Supervisor: Prof A Fazeli
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Deconvoluting the spatial multi-omic landscape of high-grade glioma to target post-surgical residual disease

University of Sheffield School of Medicine and Population Health
Background. High-grade gliomas are the most common cancers arising within the brain and contribute to ~190,000 brain tumour related deaths/year globally. Read more
 Supervisors: Dr S Collis, Dr O Rominiyi, Dr M Dunning
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Effect of androgens on preantral follicle development

University of Sheffield School of Medicine and Population Health
Polycystic ovary syndrome (PCOS) is a condition that affects >5% of women of reproductive age and is the most common cause of menstrual dysfunction and is associated with metabolic abnormalities and increased risk to long-term health. Read more
 Supervisors: Dr M Fenwick, Dr N Krone
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Antisense technologies as potential treatments for Cushing’s disease

University of Sheffield School of Medicine and Population Health
Cushing’s disease is a devastating condition caused by a pituitary corticotroph tumour that over-expresses the proopiomelanocortin gene (POMC) and secretes high levels of ACTH. Read more
 Supervisor: Dr E H Kemp
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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