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The number of completed bacterial genome sequences is increasing rapidly, and provides a rich data resource for computer-based studies aimed at understanding the composition and evolution of bacterial genomes. We also have extensive genome survey sequence data of our own on multiple isolates of rhizobia which require further analysis to elucidate the genetic structure of bacterial populations. The project will develop new tools and approaches for comparing and analysing genomes. A masters degree in bioinformatics would ideal preparation, and certainly a background in genetics and some aptitude for computer programming is important. In addition to computer-based studies, there is a possibility of some laboratory work collecting new data on genomic diversity. Our research group includes both lab- and computer-based people.
Funding Notes:
Project potentially eligible for studentship funding - pending confirmation from NERC; Please enquire for any further details
References:
Lozano L, et al. (2010) Appl. Environ. Microbiol. doi:10.1128/aem.01001-01010. [evolution of insertion sequences]
Tian CF, et al. (2010) FEMS Microbiology Ecology 73, 563-576. [multilocus population structure with recombination]
Harrison PW, et al. (2010) Trends in Microbiology 18, 141-148. [comprehensive bioinformatic analysis supporting the ‘chromid’ concept]
Bontemps C, et al. (2010) Molecular Ecology 19, 44-52. [diverse species, little recombination]
Research Assessment Exercise (RAE) 2008 Results