Find A PhD

Find A Masters

1000's of Masters Courses from across the globe

Find An MBA

MBA & Business Masters courses from the World's leading Business Schools

Spotlight

NHH - The Norwegian School of Economics and Business Administration Featured PhD Projects & Programmes

Spotlight

EPSRC Featured PhD Projects & Programmes
University of Southampton Featured PhD Projects & Programmes
University College London Featured PhD Projects & Programmes

PhD Research Project

Development of a novel bioassay for UVA-induced skin damage


More Info


Institution Location



Related PhDs


University of Central Lancashire
School of Pharmacy and Biomedical Sciences
Liverpool John Moores University
School of Sport and Exercise Sciences

Lancaster University
Biomedical and Life Sciences
Dr S Allinson
Prof T Mcmillan
No more applications being accepted
Funded PhD Project (UK Students Only)

Exposure to environmental ultraviolet radiation (UV) can cause a number of short- and long-term negative effects in human skin, including erythema (burning), skin cancer and ageing. These harmful effects can be mitigated by the application of sunscreens, with the effectiveness of these being expressed in terms of a sun protection factor (SPF) related to the UV dose required for erythema.
Longer wavelength UV (UVA; 315-400 nm) was until recently comparatively neglected in terms of its health impact and it is still the case that many sunscreens do not provide significant protection against this type of radiation. UVA exposure does not result in erythema but is able to cause skin cancer and is also considered to be the major player in UV-induced skin ageing. The standard method for assaying the effectiveness of sunscreens therefore does not adequately evaluate the protection offered against UVA. Moreover, ongoing research in our laboratories and others have shown that the cellular response to UVA is significantly different from the response to shorter wavelength UVB, and that established biomarkers of UV exposure (e.g. p53 activation) may underestimate the damage caused by UVA.
The aim of the project will be to evaluate biomarkers for UVA exposure in a biologically relevant in vitro test system to be developed as part of the project. Work carried out by Dr Allinson and Prof McMillan in collaboration with Boots has identified several potential short- and long-term biomarkers for UVA damage. These will be evaluated for robustness using different skin cell culture models.


Funding Notes:

The project is supported by a 4 year BBSRC PhD studentship, covering tuition fees plus living costs allowance of £13,590

NB:- Applicants should have at least a 2:1 Honours degree, or equivalent with a biomedical or related focus and fulfil BBSRC eligibility criteria

Please apply by sending a CV and covering letter to Dr Allinson by either email, using the link below, or post (Dr Sarah Allinson, Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, LA1 4YQ)



Spotlight

FindA University Ltd Featured PhD Projects & Programmes

Find A PhD

Copyright ©2005-2014
All rights reserved

FindAPhD is a database of PhD Projects & Programmes

FindA University Ltd, Sellers Wheel, 151 Arundel Street, Sheffield, S1 2NU, UK. Tel: +44 (0)114 213 4333 Fax: +44 (0) 114 268 5766
Cookie Policy    X