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Many bodily tissues suffer regular damage, and their efficient repair is essential for maintaining functionality. The most obvious and well studied is skin, which provides a protective barrier against the environment. Ovaries are an unusual example of repeatedly “wounded” tissue, since ovulation requires an egg to physically break through the tissue overlying the ovulatory follicle. Although there are some variations in the mechanisms of repair at different anatomical sites, the process invariably includes an inflammatory reaction, and scarring is inevitable. Our research focuses on the mechanisms underlying the fibrotic differentiation of cells in the vicinity of a skin or ovarian wound, and investigates how this process may be influenced by inflammatory mediators. Within the scope of our ongoing work, a PhD student in the lab would be encouraged to pursue the research project of greatest interest to them (e.g., skin/ovary).
The clinical, academic, and industrial collaborations inherent in all projects in the lab will provide an excellent career-developing experience. This project also provides a fantastic training opportunity since the student will gain expertise in a wide-range of techniques, ranging from in vivo experimentation and microscopy, to molecular biology.
Funding Notes:
Candidates should hold or expect a first or upper second class BSc degree or equivalent, in a subject related to mammalian cell biology, oncology or genetics, or a medical degree.
This full time post is fully funded for 48 months covering:
• a postgraduate stipend (£20,000 per annum), inclusive of London weighting.
• tuition fees for 4 years (at the Home/EU rate).
Successful candidates for the GTA studentships will be required to perform teaching duties.