PhD Research Project

My Shortlist0

This project is no longer listed in the FindAPhD database
and may not be available.

Click here to view other PhD studentship opportunities at University of York.

Regulation of dendritic cell development and function by bone marrow stromal cells during chronic inflammation (Marie Curie Early Stage Researcher in STROMA ITN)

Institution:

University of York

Dept/School/Faculty:

Department of Biology

PhD Supervisor:

Prof P M Kaye

Application Deadline:

No more applications being accepted

Funding Availability:

Funded PhD Project (Students Worldwide)

PhD Research Project

Click here to visit the University of York website

Bone marrow stromal cells play an important role in the regulation of hematopoiesis but how their function is affected by systemic inflammation is poorly understood. We have previously shown that during experimental leishmaniasis, there is an increase in the bone marrow output of myeloid precursor cells, and that stromal cells have the potential to direct the differentiation of these precursors into DCs with regulatory function. However, the identity of the stromal cell subpopulations affected by inflammation and the molecular changes they undergo are unknown. This project will combine a variety of state-of-the-art approaches in cellular immunology (including intra-vital imaging, flow sorting and transcriptomics) with models that allow stromal cell-specific gene targeting, to generate important new insights into how inflammation affects the bone marrow niche that supports the development of DCs and other myeloid cells.