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25 May, 2013
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Regulation of dendritic cell development and function by bone marrow stromal cells during chronic inflammation (Marie Curie Early Stage Researcher in STROMA ITN)
Institution:
University of York
Dept/School/Faculty:
Department of Biology
PhD Supervisor:
Prof P M Kaye
Application Deadline:
No more applications being accepted
Funding Availability:
Funded PhD Project (Students Worldwide)
This research project has funding attached. Applications for this project are welcome from suitably qualified candidates worldwide. Funding may only be available to a limited set of nationalities and you should read the full department and project details for further information.
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PhD Research Project
Bone marrow stromal cells play an important role in the regulation of hematopoiesis but how their function is affected by systemic inflammation is poorly understood. We have previously shown that during experimental leishmaniasis, there is an increase in the bone marrow output of myeloid precursor cells, and that stromal cells have the potential to direct the differentiation of these precursors into DCs with regulatory function. However, the identity of the stromal cell subpopulations affected by inflammation and the molecular changes they undergo are unknown. This project will combine a variety of state-of-the-art approaches in cellular immunology (including intra-vital imaging, flow sorting and transcriptomics) with models that allow stromal cell-specific gene targeting, to generate important new insights into how inflammation affects the bone marrow niche that supports the development of DCs and other myeloid cells.
Research Assessment Exercise (RAE) 2008 Results
Unit of Assessment:
Biological Sciences
What is the RAE?
FTE Category A Staff Submitted
4*
3*
2*
1*
U/C
57.51
25%
35%
30%
10%
0%
PJ038841-001597
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Institution Location
53.94769400
-1.04984300
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