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Prof P M Kaye
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
Bone marrow stromal cells play an important role in the regulation of hematopoiesis but how their function is affected by systemic inflammation is poorly understood. We have previously shown that during experimental leishmaniasis, there is an increase in the bone marrow output of myeloid precursor cells, and that stromal cells have the potential to direct the differentiation of these precursors into DCs with regulatory function. However, the identity of the stromal cell subpopulations affected by inflammation and the molecular changes they undergo are unknown. This project will combine a variety of state-of-the-art approaches in cellular immunology (including intra-vital imaging, flow sorting and transcriptomics) with models that allow stromal cell-specific gene targeting, to generate important new insights into how inflammation affects the bone marrow niche that supports the development of DCs and other myeloid cells.
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