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Click here to search FindAPhD.com for PhD studentship opportunitiesMembrane trafficking and human disease: Investigating how the Lowe syndrome protein OCRL1 regulates endocytosis
Prof Martin Lowe
Applications accepted all year round
About the Project
Mutation of the phosphoinositide phosphatase OCRL1 causes two disorders in humans, Lowe syndrome (LS) and Dent-2 disease. OCRL1 appears to regulate several cellular processes, including endocytic membrane traffic, ciliogenesis, cytokinesis, cell polarity and cell migration, but the mechanisms involved are poorly defined. It is also unclear how OCRL1 may regulate such varied processes. The aim of this project is to answer these questions, using the power of proteomics to systematically and unambiguously identify all of the interaction partners for OCRL1 i.e. its ‘interactome’. The interactomes for the related phosphatase INPP5B and two novel endocytic regulators that bind to both OCRL1 and INPP5B, called IPIP27A and B, will be identified in parallel. Selected novel interactions will then be analysed using both biochemical and cellular approaches to reveal how they impact upon endocytic membrane traffic and the other cellular processes listed above. Together the experiments undertaken in this project will not only increase our understanding of endocytic trafficking and various downstream cellular processes, but also reveal the molecular mechanisms responsible for the manifestations of Lowe syndrome and Dent-2 disease in humans.
Funding Notes
This is a PhD project that will be based in Manchester, UK and at a Singapore A*STAR Research Institute. It is anticipated that the project will take place as follows: Years 1 and 4 in Manchester, Years 2 and 3 in Singapore.
For further information on the programme, see: http://www.ls.manchester.ac.uk/phdprogrammes/singaporeastar
Applications are invited from UK/EU nationals who have obtained (or about to obtain) at least an upper second class honours degree in a related area. We can consider applications from non-EU nationals, however they must be able to fund the required difference in tuition fees.
For further information on the programme, see: http://www.ls.manchester.ac.uk/phdprogrammes/singaporeastar
Applications are invited from UK/EU nationals who have obtained (or about to obtain) at least an upper second class honours degree in a related area. We can consider applications from non-EU nationals, however they must be able to fund the required difference in tuition fees.
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