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  Cell cycle regulation in Arabidopsis


   School of Biological Sciences

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  Prof L Bogre  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Plant growth is tightly controlled by environmental factors. We investigate how these stress and growth stimulatory factors regulate plant growth and cell cycle. The key issues we address are:
How auxin regulate the cell cycle through the E2F-RB pathway. 2. Stem cell functions in root meristems regulated by the E2F-RB pathway. 3. Mitogen activated protein kinase signalling, systems biology approaches. 4. PDK1 signalling pathway, an environmental sensor on cortical microtubules. 5. Regulation of plant growth by S6K signalling.


References

1. Bögre L., Ökrész L., Henriques R., and Anthony R.G. (2003) Growth signalling pathways in Arabidopsis, the protein kinase AGC Trends in Plant Science Trends Plant Sci, 8, 424-431.
2. Anthony, R. G., Henriques, R., Helfer, A., Mészáros, T., Gabino R., Testerink, C., Munnik, T., Deák, M., Koncz C., and Bögre L. (2004). A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis. EMBO J. 23, 572-581.
3. Weingartner, M. Criqui, M.-C., Meszaros T., Derevier, A., Schmit A.-C. Erhardt, M. Helfer, A. Binarova P., Bögre L. and Genschik P. (2004). Expression of a non-degradable cyclin B1 affects plant development, cell shape and leads to endomitosis through abnormal cytokinetic microtubule organisation. Plant Cell 16, 643-657.
4. Leeuwen, W., Okresz, L., Bogre, L., and Munnik, T. (2004). Learning the lipid language of plant signalling. Trends in Plant Science 9:378-84
5. Magyar Z, De Veylder L, Atanassova A, Bako L, Inze D, Bogre L. (2005) The Role of the Arabidopsis E2FB Transcription Factor in Regulating Auxin-Dependent Cell Division. Plant Cell. 17(9):2527-41

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 About the Project