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Prof Colin Campbell
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Competition Funded PhD Project (European/UK Students Only)
About the Project
Medical Research Scotland
PhD Studentship Awards
This project is one of six four-year PhD Studentships funded by Medical Research Scotland (http://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and Company. The Studentships will provide the first-class academic and commercial training needed to equip the successful student for a science career in an increasingly competitive market.
Systems redox biology analysis of a novel family of naturally-derived anti-oxidants/anti-inflammatories - Delivered by the University of Edinburgh and Aquapharm Biodiscovery Ltd (http://www.aquapharm.co.uk).
Academic Supervisors: Dr Colin Campbell & Dr Dominic Campopiano; Company Supervisor: Dr Tim Morley
The regulation of cellular redox potential is important in controlling the behaviour of healthy cells and its dysregulation is implicated in the initiation and proliferation of several disease states. Redox potential is a measure of the driving force for oxidation and oxidative changes are known to be important in the initiation or proliferation of a variety of diseases including arthritis, chronic obstructive pulmonary disease (COPD), Alzheimer's disease, age-related macular degeneration and multiple sclerosis. Aquapharm Biodiscovery Ltd. has recently discovered a new family of molecules which have therapeutic potential as anti-oxidants or anti-inflammatory drugs in diseases such as those listed above. It is thought that this family of molecules works by interacting with pathways involved in cellular redox regulation. Our aim in this project is to use a combination of cutting-edge biophysical techniques, established molecular biology assays and a new approach to visualisation and interpretation of this data to understand the mode of action of Aquapharm's therapeutic molecules with a view to optimising their effect. Through combining quantitative measurements with a systems biology approach we will produce a quantitative map of redox potential distribution in the cell that offers a completely new way to analyse the effects of molecules which alter redox-regulation.
PhD Studentship Awards
This project is one of six four-year PhD Studentships funded by Medical Research Scotland (http://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and Company. The Studentships will provide the first-class academic and commercial training needed to equip the successful student for a science career in an increasingly competitive market.
Systems redox biology analysis of a novel family of naturally-derived anti-oxidants/anti-inflammatories - Delivered by the University of Edinburgh and Aquapharm Biodiscovery Ltd (http://www.aquapharm.co.uk).
Academic Supervisors: Dr Colin Campbell & Dr Dominic Campopiano; Company Supervisor: Dr Tim Morley
The regulation of cellular redox potential is important in controlling the behaviour of healthy cells and its dysregulation is implicated in the initiation and proliferation of several disease states. Redox potential is a measure of the driving force for oxidation and oxidative changes are known to be important in the initiation or proliferation of a variety of diseases including arthritis, chronic obstructive pulmonary disease (COPD), Alzheimer's disease, age-related macular degeneration and multiple sclerosis. Aquapharm Biodiscovery Ltd. has recently discovered a new family of molecules which have therapeutic potential as anti-oxidants or anti-inflammatory drugs in diseases such as those listed above. It is thought that this family of molecules works by interacting with pathways involved in cellular redox regulation. Our aim in this project is to use a combination of cutting-edge biophysical techniques, established molecular biology assays and a new approach to visualisation and interpretation of this data to understand the mode of action of Aquapharm's therapeutic molecules with a view to optimising their effect. Through combining quantitative measurements with a systems biology approach we will produce a quantitative map of redox potential distribution in the cell that offers a completely new way to analyse the effects of molecules which alter redox-regulation.
Funding Notes
The PhD Studentship provides: an annual tax-free stipend of £16,000, increasing to £16,500 over the four years; tuition fees at UK/EU rates only; and consumables. Please note international fees are not covered.
Applicants should have a minimum of an upper second-class degree or its equivalent, in chemistry or a related life-science subject.
Applications should be made using the University of Edinburgh's postgraduate admissions page: http://www.ed.ac.uk/studying/postgraduate/degrees?id=16&cw_xml=details.php
Applicants should have a minimum of an upper second-class degree or its equivalent, in chemistry or a related life-science subject.
Applications should be made using the University of Edinburgh's postgraduate admissions page: http://www.ed.ac.uk/studying/postgraduate/degrees?id=16&cw_xml=details.php
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Career overview
Professor Colin Campbell is the Head of the Organic Chemistry Section and co-Head of the IRR Chemistry Hub at the University of Edinburgh. He has previously served as the Director of the EPSRC and MRC Centre for Doctoral Training in Optical Medical Imaging (OPTIMA). Professor Campbell was a Fulbright Awardee during the 2018-2019 academic year and held the position of Sabbatical Professor at the Biofrontiers Institute, University of Colorado, Boulder, during the same period. His research focuses on nanosensors, electrochemistry, Surface Enhanced Raman Spectroscopy (SERS), nanotechnology, and redox biology. Professor Campbell's group has pioneered the use of SERS to make measurements in 3D tissue models and has developed new sensors for measuring pH, redox potential, enzyme activity, and the concentration of small molecules. The collaborative nature of his work has facilitated access to patient materials, enabling advancements in the application of SERS in biology and medicine.
Research interests
Professor Colin Campbell's research focuses on nanosensors, electrochemistry, Surface Enhanced Raman Spectroscopy (SERS), nanotechnology, and redox biology. They have pioneered the use of SERS to make measurements in 3D tissue models, developing new sensors to measure pH, redox potential, enzyme activity, and the concentration of small molecules. Their work involves creating new materials for SERS that enable research in complex biological microenvironments. Professor Campbell's collaborative approach has provided access to patient materials, advancing the application of SERS in biology and medicine. Current research interests include developing new sensors, incorporating sensors into 3D tissue models, and making measurements in tissue and biofluids. Additionally, they engage in knowledge exchange by turning scientific data and ideas into music as a means of communicating scientific concepts.
