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Prof M Salmeron-Sanchez
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
The School of Engineering at the University of Glasgow is seeking a highly motivated graduate to undertake an exciting 3.5 year PhD project
“Materials-based strategies to engineer the cellular microenvironment”
Prof. Manuel Salmeron-Sanchez
Project Description
The School of Engineering of the University of Glasgow is seeking a highly motivated graduate to undertake an exciting 3.5-year PhD project entitled ‘Materials-based strategies to engineer the cellular microenvironment’ within the Biomedical Engineering Division.
The overarching theme of this proposal is the engineering of advanced materials-based strategies for controlled tissue repair and regeneration, including the differentiation of stem cells. In vivo, adult stem cells, such as mesenchymal stem cells (MSCs) reside in a niche. The niche microenvironment acts to regulate quiescence, self-renewal and differentiation in response to tissue demand. We intend to mimic cellular microenvironments by engineering materials able to control the assembly of the extracellular matrix proteins (the artificial matrix) in a physiological way. We will explore the interaction of these artificial matrices with relevant growth factors under well-defined conditions, and we will investigate cell interactions with these systems, seeking to promote tissue regeneration
This PhD project will tie into an existing local collaboration between Prof. Manuel Salmeron-Sanchez (Division of Biomedical Engineering, School of Engineering) and Dr. Matthew Dalby (Center for Cell Engineering); the PhD candidate will be expected to spend time at both laboratories. The PhD candidate will be trained in the engineering and physico-chemical characterization of biomaterials and surfaces, protein adsorption and characterization techniques, cell culture, various molecular biology techniques (e.g., Western blotting, real time polymerase chain reaction), and several microscopy techniques (fluorescence microscopy, confocal microscopy, atomic force microscopy). As the candidate progresses through the project, he/she will be encouraged to develop the project further and will be expected to work independently.
How to apply
Application for this scholarship is made by using the online system at the following link for admission as a postgraduate research student to the Graduate School of the College of Science and Engineering:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
It should be noted that this application is to gain admission to our PGR programme with the decision on this being based on your academic achievements, and an offer of admission may be sent out before a decision on this Scholarship is made. Candidates applying for this Scholarship will have their applications further vetted as to acceptability to this Scholarship and will most likely have an interview/discussion with the supervisor before any decision is made
Contacts
For an informal discussion or for further information on this project, potential applicants are encouraged to contact:
Prof. Manuel Salmeron-Sanchez
[Email Address Removed]
Closing date – June 30th 2013
“Materials-based strategies to engineer the cellular microenvironment”
Prof. Manuel Salmeron-Sanchez
Project Description
The School of Engineering of the University of Glasgow is seeking a highly motivated graduate to undertake an exciting 3.5-year PhD project entitled ‘Materials-based strategies to engineer the cellular microenvironment’ within the Biomedical Engineering Division.
The overarching theme of this proposal is the engineering of advanced materials-based strategies for controlled tissue repair and regeneration, including the differentiation of stem cells. In vivo, adult stem cells, such as mesenchymal stem cells (MSCs) reside in a niche. The niche microenvironment acts to regulate quiescence, self-renewal and differentiation in response to tissue demand. We intend to mimic cellular microenvironments by engineering materials able to control the assembly of the extracellular matrix proteins (the artificial matrix) in a physiological way. We will explore the interaction of these artificial matrices with relevant growth factors under well-defined conditions, and we will investigate cell interactions with these systems, seeking to promote tissue regeneration
This PhD project will tie into an existing local collaboration between Prof. Manuel Salmeron-Sanchez (Division of Biomedical Engineering, School of Engineering) and Dr. Matthew Dalby (Center for Cell Engineering); the PhD candidate will be expected to spend time at both laboratories. The PhD candidate will be trained in the engineering and physico-chemical characterization of biomaterials and surfaces, protein adsorption and characterization techniques, cell culture, various molecular biology techniques (e.g., Western blotting, real time polymerase chain reaction), and several microscopy techniques (fluorescence microscopy, confocal microscopy, atomic force microscopy). As the candidate progresses through the project, he/she will be encouraged to develop the project further and will be expected to work independently.
How to apply
Application for this scholarship is made by using the online system at the following link for admission as a postgraduate research student to the Graduate School of the College of Science and Engineering:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/applyonline/
It should be noted that this application is to gain admission to our PGR programme with the decision on this being based on your academic achievements, and an offer of admission may be sent out before a decision on this Scholarship is made. Candidates applying for this Scholarship will have their applications further vetted as to acceptability to this Scholarship and will most likely have an interview/discussion with the supervisor before any decision is made
Contacts
For an informal discussion or for further information on this project, potential applicants are encouraged to contact:
Prof. Manuel Salmeron-Sanchez
[Email Address Removed]
Closing date – June 30th 2013
Funding Notes
This Scholarship is supported by the School of Engineering, and it will cover the tuition fees and provide a stipend of £13,590 per annum for 3.5 years.
To be eligible for this Scholarship, applicants must be nationals of the UK or EU.
To be eligible for this Scholarship, applicants must be nationals of the UK or EU.
References
McMurray, R.J., Gadegaard, N., Tsimbouri, P.M., Burgess, K.V., McNamara, L.E., Tare, R., Murawski, K., Kingham, E., Oreffo, R.O.C., and Dalby, M.J. (2011) Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nature Materials, 10 (8). pp. 637-644
Tsimbouri, P.M., Murawski, K., Hamilton, G., Herzyk, P., Oreffo, R.O.C., Gadegaard, N., and Dalby, M.J. (2013) A genomics approach in determining nanotopographical effects on MSC phenotype. Biomaterials, 34 (9). pp. 2177-2184.
Saadeddin, A., Rodrigo-Navarro, A., Monedero, V., Rico, P., Moratal, D., González-Martín, M.L., Navarro, D., García, A.J., and Salmerón-Sánchez, M. (2013) Functional living biointerphases. Advanced Healthcare Materials . ISSN 2192-2640 (doi:10.1002/adhm.201200473) (In Press)
González-García, C., Moratal, D., Oreffo, R.O.C., Dalby, M.J., and Salmerón-Sánchez, M. (2012) Surface mobility regulates skeletal stem cell differentiation. Integrative Biology, 4 (5). pp. 531-539. ISSN 1757-9694 (doi:10.1039/c2ib00139j)
Tsimbouri, P.M., Murawski, K., Hamilton, G., Herzyk, P., Oreffo, R.O.C., Gadegaard, N., and Dalby, M.J. (2013) A genomics approach in determining nanotopographical effects on MSC phenotype. Biomaterials, 34 (9). pp. 2177-2184.
Saadeddin, A., Rodrigo-Navarro, A., Monedero, V., Rico, P., Moratal, D., González-Martín, M.L., Navarro, D., García, A.J., and Salmerón-Sánchez, M. (2013) Functional living biointerphases. Advanced Healthcare Materials . ISSN 2192-2640 (doi:10.1002/adhm.201200473) (In Press)
González-García, C., Moratal, D., Oreffo, R.O.C., Dalby, M.J., and Salmerón-Sánchez, M. (2012) Surface mobility regulates skeletal stem cell differentiation. Integrative Biology, 4 (5). pp. 531-539. ISSN 1757-9694 (doi:10.1039/c2ib00139j)
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