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Dr Z Sienkiewicz
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
People are increasingly exposed to radiofrequency (RF) fields fields from mobile phones and base stations, and from wireless local area networks and WiFi. There are gaps in knowledge about how RF fields cause biological effects and although no hazards have been identified at environmental levels of exposure, uncertainties remain about neurobiological effects, especially in children and the elderly.
Recent studies with an animal model of Alzheimer’s disease suggest a protective effect of chronic exposure to low level RF fields. This could impact on the treatment of neurodegenerative diseases and urgently requires further validation of the findings and investigation of the underlying mechanisms.
The overall aim of this project is to examine the potential of RF fields to cause biological effects in Alzheimer’s disease mice, and to define the conditions under which these effects may occur.
Objectives
1. To investigate effect of RF exposure on the learning, memory and anxiety in Alzheimer’s disease mice.
2. To investigate consequences of RF exposure on the pathological progression of Alzheimers disease.
3. To discover whether adult neurogenesis is affected by RF fields.
The successful candidate will benefit from extensive training in a wide range of methods including in vivo behavioural analysis, and molecular biology as well as techniques in histology and immunohistochemistry.
The student should have, or expect to gain, a first or strong upper second class degree (or equivalent) in a relevant biological sciences discipline.
This is a joint PhD project between the PHE and the University of Oxford, Department of Pharmacology.
The Non-Ionising Radiation Effects (NIRE) group at PHE has been carrying out research into the physiological and behavioural effects of RF and other electromagnetic fields for over 25 years. Interests include investigating mechanisms whereby low level exposures could lead to biological changes, and the late effects of early exposures. The group has published over 30 indexed papers and more than 20 reviews.
The Experimental Neuropathology Laboratory in the Department of Pharmacology, university of Oxford was established in 2000, and over 100 peer reviewed papers have been published by the laboratory.
Successful candidates also require acceptance by the University of Oxford so please refer to the University of Oxford Graduate Students pages for details of eligibility http://www.ox.ac.uk/admissions/postgraduate_courses/apply/application_guide.html).
This position will be supported by Somerville College.
Informal enquiries should be directed to Dr Zenon Sienkiewicz at PHE (telephone 01235 825123 or e-mail [Email Address Removed])
Recent studies with an animal model of Alzheimer’s disease suggest a protective effect of chronic exposure to low level RF fields. This could impact on the treatment of neurodegenerative diseases and urgently requires further validation of the findings and investigation of the underlying mechanisms.
The overall aim of this project is to examine the potential of RF fields to cause biological effects in Alzheimer’s disease mice, and to define the conditions under which these effects may occur.
Objectives
1. To investigate effect of RF exposure on the learning, memory and anxiety in Alzheimer’s disease mice.
2. To investigate consequences of RF exposure on the pathological progression of Alzheimers disease.
3. To discover whether adult neurogenesis is affected by RF fields.
The successful candidate will benefit from extensive training in a wide range of methods including in vivo behavioural analysis, and molecular biology as well as techniques in histology and immunohistochemistry.
The student should have, or expect to gain, a first or strong upper second class degree (or equivalent) in a relevant biological sciences discipline.
This is a joint PhD project between the PHE and the University of Oxford, Department of Pharmacology.
The Non-Ionising Radiation Effects (NIRE) group at PHE has been carrying out research into the physiological and behavioural effects of RF and other electromagnetic fields for over 25 years. Interests include investigating mechanisms whereby low level exposures could lead to biological changes, and the late effects of early exposures. The group has published over 30 indexed papers and more than 20 reviews.
The Experimental Neuropathology Laboratory in the Department of Pharmacology, university of Oxford was established in 2000, and over 100 peer reviewed papers have been published by the laboratory.
Successful candidates also require acceptance by the University of Oxford so please refer to the University of Oxford Graduate Students pages for details of eligibility http://www.ox.ac.uk/admissions/postgraduate_courses/apply/application_guide.html).
This position will be supported by Somerville College.
Informal enquiries should be directed to Dr Zenon Sienkiewicz at PHE (telephone 01235 825123 or e-mail [Email Address Removed])
Funding Notes
EU applicants must demonstrate a relevant connection to the UK through ordinary residence. As a UK public funded body, PHE cannot fund applicants from outside the EU.
PHE matches MRC stipend rates which are currently £13,726pa (outside London).
PHE matches MRC stipend rates which are currently £13,726pa (outside London).
References
Anthony DC, Couch Y, Losey P, Evans MC. (2012) The systemic response to brain injury and disease. Brain Behav Immun.26(4):534-40.
Anthony, D.C. & Perry, V.H. Inflammation and neurodegeneration: Molecules and mechanisms. Journal of Psychopharmacology 14, A9 (2000)
Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, Zhang G, Sava V, Tan J, Cao C (2010). Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice. J Alzheimers Dis 19(1):191-210.
Broom KA, Whitehill, K and Sienkiewicz, ZJ. Effects of mobile phone signals on neurobiology. Mutagenesis (2012) 27(1):121.
Broom KA, Anthony DC, Lowe JP, Griffin JL, Scott H, Blamire AM, Styles P, Perry VH, Sibson NR. MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. Neurobiol Dis. 2007 26(3):707-17.
Sienkiewicz ZJ, Jones N and Bottomley A (2005). Neurobehavioural effects of electromagnetic fields. Bioelectromagnetics, Suppl 7, S116-26
Anthony, D.C. & Perry, V.H. Inflammation and neurodegeneration: Molecules and mechanisms. Journal of Psychopharmacology 14, A9 (2000)
Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, Zhang G, Sava V, Tan J, Cao C (2010). Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice. J Alzheimers Dis 19(1):191-210.
Broom KA, Whitehill, K and Sienkiewicz, ZJ. Effects of mobile phone signals on neurobiology. Mutagenesis (2012) 27(1):121.
Broom KA, Anthony DC, Lowe JP, Griffin JL, Scott H, Blamire AM, Styles P, Perry VH, Sibson NR. MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. Neurobiol Dis. 2007 26(3):707-17.
Sienkiewicz ZJ, Jones N and Bottomley A (2005). Neurobehavioural effects of electromagnetic fields. Bioelectromagnetics, Suppl 7, S116-26
