Find A PhD

Find A Masters

1000's of Masters Courses from across the globe

Find An MBA

MBA & Business Masters courses from the World's leading Business Schools

Spotlight

University of Birmingham Featured PhD Projects & Programmes [{"Id":47905,"Type":"M","Filename":"manchester-computer14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48046,"Type":"M","Filename":"bham-distance14.gif","Institution":"University of Birmingham","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48083,"Type":"M","Filename":"menu_york_biol5.gif","Institution":"University of York","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48107,"Type":"M","Filename":"menu_manchester14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48113,"Type":"M","Filename":"reading-grad.gif","Institution":"University of Reading","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48179,"Type":"M","Filename":"menu_munich.gif","Institution":"Ludwig-Maximilians-Universität Munich","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48233,"Type":"M","Filename":"warwick-bus14.gif","Institution":"University of Warwick","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48257,"Type":"M","Filename":"Leeds-Open14.gif","Institution":"University of Leeds","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

Spotlight

University of Bristol Featured PhD Projects & Programmes
University of Oxford Featured PhD Projects & Programmes
King’s College London Featured PhD Projects & Programmes
[{"Id":47668,"Type":"L","Filename":"/ucl-imaging13.gif","Institution":"University College London","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":47923,"Type":"L","Filename":"epsrc2014.gif","Institution":"EPSRC","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48165,"Type":"L","Filename":"soton-chem14.gif","Institution":"University of Southampton","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48166,"Type":"L","Filename":"soton-bios14.gif","Institution":"University of Southampton","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48192,"Type":"L","Filename":"tmcs-epsrcB.gif","Institution":"University of Bristol","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48211,"Type":"L","Filename":"impchem14.gif","Institution":"Imperial College London","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48238,"Type":"L","Filename":"cancer-mrc1.gif","Institution":"University of Cambridge","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48252,"Type":"L","Filename":"sussex-neuro2013.gif","Institution":"University of Sussex","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48266,"Type":"L","Filename":"nrp-rotation14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48267,"Type":"L","Filename":"nrp-dtp14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48268,"Type":"L","Filename":"nrp-ifr14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48269,"Type":"L","Filename":"nrp-TGAC14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48270,"Type":"L","Filename":"nrp-JIC14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48271,"Type":"L","Filename":"nrp-TSL14.gif","Institution":"Norwich Research Park","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48274,"Type":"L","Filename":"oxford-biochem.gif","Institution":"University of Oxford","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48288,"Type":"L","Filename":"maxplanck14.gif","Institution":"Max Planck","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48292,"Type":"L","Filename":"kcl-kbi14c.gif","Institution":"King’s College London","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48297,"Type":"L","Filename":"hardiman-13.gif","Institution":"National University of Ireland, Galway","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48299,"Type":"L","Filename":"oxfo-weatherall12.gif","Institution":"University of Oxford","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48301,"Type":"L","Filename":"ntu-bus14.jpg","Institution":"Nottingham Trent University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48307,"Type":"L","Filename":"ljmu14.gif","Institution":"Liverpool John Moores University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48309,"Type":"L","Filename":"bris-swwdtp2.gif","Institution":"University of Bristol","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48314,"Type":"L","Filename":"RGR_mini14.gif","Institution":"FindA University Ltd","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

PhD Research Project

BBSRC MIBTP - Understanding nuclear functions of ribosomal proteins in synchronising gene expression during growth.


More Info


Institution Location



Related PhDs


University of Nottingham
School of Physics and Astronomy
University of Birmingham
School of Biosciences
University of Birmingham
School of Biosciences
University of Birmingham
School of Biosciences

School of Biosciences
Dr S Brogna
Dr Aditi Kanhere
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)

Gene expression is the process that leads from gene to active protein. The process involves three fundamental steps in eukaryotic organisms such as animals: transcription of DNA into RNA, processing of the primary transcript (pre-mRNA) and then translation of the mRNA into protein. Similar to other complex biochemical processes, the different steps of gene expression are coordinated in the cell. There are two levels of coordination; one involves coupling between the different biochemical reactions, for example, pre-mRNA processing reactions such as splicing of introns are coupled to transcription so that the newly synthesized RNA is still attached to the RNA polymerase while it is spliced; the other level of coordination requires synchronized expression of several genes to produce a given functional output. For example, the cell capacity to synthesize proteins is strictly dependent on the number of ribosomes present, so during growth the number of ribosomes must be doubled before cell division. The ribosome, however, is one of the most complex molecular machines in the cell, composed of about 80 different proteins and 4 RNAs. The building of such a complex machine requires synchronized expression of hundreds of genes. How cells achieve this level of synchronization is not well understood, particularly in multicellular organisms. This research project aims to understand these mechanisms in the fruit fly Drosophila melanogaster which is one of the most amenable model organisms used in many labs throughout the world. We envisage that the results of this research will advance our knowledge of basic cellular processes and, because about 70% of disease associated genes are conserved between Drosophila and humans, lead to a better understanding of human diseases, which, like cancer, are often the result of the failure of mechanisms that coordinate ribosome production with growth.


Funding Notes:

This studentship is competition funded by the BBSRC MIBTP scheme: http://www.birmingham.ac.uk/research/activity/mibtp/index.aspx

Deadline: January 31, 2014

Number of Studentships available: 30

Stipend: £ 13,726 per annum (plus £600 travel allowance in year 1, and a MacBook Pro)

The Midlands Integrative Biosciences Training Partnership (MIBTP) is a BBSRC-funded doctoral training partnership between the universities of Warwick, Birmingham and Leicester. It delivers innovative, world-class research training across the Life Sciences to boost the growing Bioeconomy across the UK.

To check your eligibility to apply for this project please visit: http://www2.warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/


References:

• Al-Jubran K.,Wen J., Chaudhury SR, Li M., Abdullahi A., Ramanathan P., Matina T., De S., Piechocki K., Rugjee KN and Brogna S. Visualization of the Joining of Ribosomal Subunits Reveals the Presence of 80S Ribosomes in the Nucleus. RNA 19: 1-16, 2013.

• Rugjee, K.N. Chaudhury, S.R., Al-Jubran, K., Ramanathan, P., Matina, T., Wen, J. and Brogna, S. Fluorescent protein tagging confirms the presence of ribosomal proteins at Drosophila polytene chromosomes. PeerJ, 2013, e15.

• De S, Brogna S. Are ribosomal proteins present at transcription sites on or off ribosomal subunits? Biochem Soc Trans. 38:1543-7. 2010.

• Brogna S, Sato T and Rosbash M.
Ribosome components are associated with sites of transcription
Molecular Cell 10:93–104. 2002.



Spotlight

FindA University Ltd Featured PhD Projects & Programmes [{"Id":47724,"Type":"SS","Filename":"nus-ngs14c.gif","Institution":"National University of Singapore","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":47993,"Type":"SS","Filename":"rgr_sky14.gif","Institution":"FindA University Ltd","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48106,"Type":"SS","Filename":"manc-bbsrc14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48109,"Type":"SS","Filename":"manc-epsrc14.gif","Institution":"University of Manchester","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48157,"Type":"SS","Filename":"bham-open14.gif","Institution":"University of Birmingham","TypeName":"Discipline Sponsorship Button","IntroText":"Postgraduate Open Day at the University of Birmingham, 3rd December 2014","LinkText":""},{"Id":48263,"Type":"SS","Filename":"kyushu-IEI.gif","Institution":"Kyushu University","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48276,"Type":"SS","Filename":"bath14.gif","Institution":"University of Bath","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""},{"Id":48278,"Type":"SS","Filename":"Leeds-scholar15.gif","Institution":"University of Leeds","TypeName":"Discipline Sponsorship Button","IntroText":"","LinkText":""}]

Find A PhD

Copyright ©2005-2014
All rights reserved

FindAPhD is a database of PhD Projects & Programmes

FindA University Ltd, Sellers Wheel, 151 Arundel Street, Sheffield, S1 2NU, UK. Tel: +44 (0)114 213 4333 Fax: +44 (0) 114 268 5766
Cookie Policy    X