Prof M C Wright
Applications accepted all year round
About the Project
The human gut is a key barrier between the external environment and the body and contains a vast number and array of microorganisms essential for life. However, it is becoming clear that clinically important changes in gut permeability may occur as a result of alcohol ingestion, obesity, diabetes and pancreatitis.
The hypothesis of this project is that changes in gut permeability increase the bioavailability (and toxicity) of hepatotoxic hydrophilic drugs and chemicals and that in combination with increased gut permeability to gut flora components, leads to a potentiated injurious burden in tissues (and over time, increases in chronic disease). This hypothesis will be tested in the research laboratories at Newcastle. However, the student will be expected to visit the European Food safety Authority in Parma (Italy) in order to learn how additives to food are assessed for safety.
Funding Notes
Sponsor: Medical Research Council MRC (http://www.mrc.ac.uk)
Depending on how you meet the MRC’s eligibility criteria, you may be entitled to a full or a partial award. A full award covers tuition fees at the UK/EU rate and an annual stipend of £13,726 (2013/14). A partial award covers fees at the UK/EU rate only.
References
You should have, or expect to achieve, a first-class or upper-second-class Honours degree, in a relevant subject. The student will be expected to take the MRes course if not already taken, and would be expected to take the Toxicology module and other related modules. Candidates already having taken the MRes are encouraged to apply.
You must apply through the University’s online postgraduate application form ( http://www.ncl.ac.uk/postgraduate/apply/) inserting the reference number CL075 and selecting 'Master of Research/Doctor of Philosophy (Medical Sciences) - Toxicology' as the programme of study. Only mandatory fields need to be completed (no personal statement required) and a covering letter, CV and (if English is not your first language) a copy of your English language qualifications must be attached. The covering letter must state the title of the studentship, quote the reference number CL075 and state how your interests and experience relate to the project.
You should also send your covering letter and CV to
Professor Matthew Wright Tel +44 191 208 7094 email m.c.wright@ncl.ac.uk
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