Evaluating how autoreactive T cells promote progression of colorectal cancer

The immune system can recognise colorectal cancer (CRC) cells. In particular, T cells may control the growth and spread of cancer. Some T cells appear to recognise tumour cells exclusively i.e. they do not recognise any other cell in the body (tumour-specific T cells) whereas others recognise both tumour cells and normal cells (self or autoreactive T cells). In the context of CRC, it is unclear whether both types of T cells participate in the control of cancer growth. We hypothesise that T cell responses to tumour-specific antigens are beneficial whilst those specific for tumour-associated autoantigens may be detrimental. The study aims to test this hypothesis by measuring T cell responses to both types of antigen in patients with CRC and examining their association with disease recurrence post tumour resection. Such information could be used to improve prognostication and help direct adjuvant treatment strategies.

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