Malaria and TB Systems Pharmacology at Liverpool School of Tropical Medicine on FindAPhD.com

This project is no longer listed on FindAPhD.com and may not be available.

Click here to search FindAPhD.com for PhD studentship opportunities

Dr G Biagini No more applications being accepted Competition Funded PhD Project (Students Worldwide)

About the Project

We are in possession of a number of novel hit molecules active against TB and the malaria parasite. The objective of the projects will be to determine the molecular mode of action (MoA) using an array of technologies, including;
(i) the synthesis and use of chemical “click” probes,
(ii) pharmacometabolomics (using both NMR and LC-MS/MS) and
(iii) high-content imaging.

These techniques are complimentary and allow
(i) the identification of inhibitors with novel MoA,
(ii) an insight into the biological targets and
(iii) prioritisation of hits for onward drug development.

Project will be tailored to meet the interests of perspective candidates.

Funding Notes

Studentships are for full time students only and for a period of three years. Students will receive an award equivalent to the Research Council stipend (Home/EU level) and a contribution towards their running costs of £5,000 per year.

LSTM will fund fees for students supported by these studentships at the Home/EU level. There will be no additional funding available for students requiring international fees. Applicants paying international level fees will need to find additional funding from alternative sources.

The studentships will be awarded to excellent students following a rigorous short-listing procedure and interview process.

References

AntoineT, Fisher N, Amewu R, O'Neill PM, Ward SA, Biagini GA. Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of membrane potential J Antimicrob Chemother. (2014) 69(4):1005-16.

Ashley J. Warman AJ, Rito TS, Fisher NE, Moss DM, Berry NG, O’Neill PM, Ward SA, Biagini GA (2013) Antitubercular pharmacodynamics of phenothiazines Journal of Antimicrobial Chemotherapy 68:869-80

Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, Pacorel B, Lawrenson AS, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Stocks PA, Nixon GL, Chadwick J, Hemingway J, Delves MJ, Sinden RE, Zeeman AM, Kocken CH, Berry NG, O'Neill PM, Ward SA. (2012) Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proc Natl Acad Sci U S A. 109(21):8298-303.

Fisher N, Abd Majid R, Antoine T, Al-Helal M, Warman AJ, Johnson DJ, Lawrenson AS, Ranson H, O'Neill PM, Ward SA, Biagini GA. (2012) Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression. J Biol Chem. 287:9731-41

Nixon GL, Pidathala C, Shone AE, Antoine T, Fisher N, O'Neill PM, Ward SA, Biagini GA. Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era. Future Med Chem. (2013) 5(13):1573-91.

Malaria and TB Systems Pharmacology

Liverpool School of Tropical Medicine Molecular and Biochemical Parasitology Group

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

Funding Notes

References

Select your nearest city

Do you want hassle-free information and advice?