A radiobiologically based model for combining external beam (EBRT) and moleculary targeted radiotherapy (mTRT)

The challenge when combining different radiation modalities (EBRT and mTRT) in the treatment of cancer, is to provide a framework in which the energy deposited (the dose expressed in Joule) can be related to a biological effect (DNA damage)1. This becomes imperative when informing a clinical regime that aims to combine EBRT and TRT. The aim of this DPhil project will be to develop a model that relates dose to DNA damage that results in a formalism for combining EBRT and TRT. This project will primarily involve Monte Carlo calculations of DNA damage by charged particles, and the mathematical modelling of repair so as to quantify the impact of both modalities in a consistent framework and come to re-interpretation of concepts like Biologically Effective Dose (BED) and Effective Uniform Dose (EUD). This project would suit an enthusiastic student with a background in physics/bioengineering/medical physics who is interested in the optimisation of radiation therapy for cancer patients.