Magnetic Nanoparticles for Cancer Therapy at University of Sheffield on FindAPhD.com

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Dr H Bryant No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

BRCA1/2 deficient Prostate Cancer (and BRCA-like tumours) are specifically sensitive to DNA damaging agents. Magnetic Nano-particles (MNPs) are selectively retained in tumours (due to EPR effects) and can be activated to emit heat. In addition BRCA2 is degraded when cells are heated in a laboratory incubator. Here we will bring these findings together to develop a novel way to induce BRCA2 deficiency in BRCA wild type prostate cancer cells and thus induce chemosensitivity.

Fluorescently tagged MNPs and FACS will assess optimal delivery of MNPs to tumours. MNPs will be excited in cells using a magnetic field and expression of BRCA2 and sensitivity to chemotherapeutics determined.

This is an innovative method of treating many different prostate cancer patients. The project will span biology and chemistry giving the student a unique cross-disciplinary training in developing novel techniques for cancer therapy.

Funding Notes

The Faculty Scholarships for Medicine, Dentistry & Health cover fees and stipend at Home/EU level. Overseas students may apply but will need to fund the fee differential between Home and Overseas rate from another source.

Where will I study?

University of Sheffield

Our University has a reputation for world-class teaching and research excellence across a variety of disciplines. At Sheffield, you’re welcomed into a diverse, supportive community of scholars from all over the world.

Magnetic Nanoparticles for Cancer Therapy

University of Sheffield Department of Oncology and Metabolism

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

Funding Notes

Where will I study?

University of Sheffield

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