Regulation of corticotropin-releasing hormone (CRH) neuron excitability

Our laboratory focuses on understanding how the excitability of corticotropin-releasing hormone (CRH) neurons are regulated. CRH neurons are activated in response to stress and are responsible for controlling the levels of stress hormones in the body. We are particularly interested in determining how synaptic inputs and neuromodulators regulate CRH neuron activity and function both before and after stress. This PhD project will involve performing electrical recordings from CRH neurons in brain slices from mice, filling these neurons with dyes and reconstructing their morphology. The effects of neuromodulators on CRH neuron excitability will also be investigated. For more information on this and other projects, please contact Dr Karl Iremonger.