or
Continue with FacebookLooking to list your PhD opportunities? Log in here.
This project is no longer listed on FindAPhD.com and may not be available.
Click here to search FindAPhD.com for PhD studentship opportunities
Dr D Ungar
No more applications being accepted
Self-Funded PhD Students Only
About the Project
Protein glycosylation is known to be essential for tissue integrity and human development. It is therefore not surprising that many devastating illnesses are associated with alterations in glycosylation. Despite their known importance, the control of oligosaccharide (aka glycan) biosynthesis, and glycan function are poorly understood. Our interest is in the connection between the intra-Golgi sorting of glycosylation enzymes and the ensuing pathophysiological glycan alterations. We have developed Drosophila melanogaster models whose genetic defects cause glycosylation defects arising from Golgi-missorting. This project will characterise the phenotypes of these flies and correlate them with the glycotypes determined through mass spectrometric glycan profiling. Our results will help to understand the glycobiology of both developmental glycosylation disorders, and more wide spread diseases such as cancers or chronic inflammation in which glycosylation changes are well documented during pathology.
References
Further reading:
Ungar D (2009) Golgi linked protein glycosylation and associated diseases, Sem. Cell Dev. Biol., 20, 762-769
Miller VJ et al. (2013) Molecular insights into vesicle tethering at the Golgi by the Conserved Oligomeric Golgi (COG) complex and the golgin TMF. J. Biol. Chem., 288, 4229-4240
Ungar D (2009) Golgi linked protein glycosylation and associated diseases, Sem. Cell Dev. Biol., 20, 762-769
Miller VJ et al. (2013) Molecular insights into vesicle tethering at the Golgi by the Conserved Oligomeric Golgi (COG) complex and the golgin TMF. J. Biol. Chem., 288, 4229-4240
How good is research at University of York in Biological Sciences?
Research output data provided by the Research Excellence Framework (REF)
Click here to see the results for all UK universities
