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  Investigations into Electron Transfer from Cancer Cells using Nanostructured Surfaces


   School of Chemical Engineering

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Prof P Mendes  Applications accepted all year round  Competition Funded PhD Project (Students Worldwide)

About the Project

Just as biology is offering inspiration and components for nanotechnology, nanotechnology is providing new tools and technology platforms to measure, understand and control biological systems [1]. Current research has led to the development of novel nano-structured surfaces as electrochemical platforms to study electron transfer from bacteria for applications within microbial fuel cell development and biosensor research [2]. Moreover, investigating the mechanism of electron transfer from cells allows for a greater understanding of fundamental biology behind such processes [3]. However, little research has been performed on investigating electron transfer to electrodes from eukaryotic cells.
Cancers cells have been shown to have increased numbers of membrane electron transport systems (tPMETs). These convey a metabolic advantage for the cancer cells enabling them to have a high rate of proliferation.
The aim of the proposed investigation is to fabricate nano-structured electrodes allowing for individual ‘wiring’ and control of these electron transport systems. Consequently, by ‘wiring’ in to membrane electron transport systems and controlling electron transfer events it should be possible to halt/slow cell proliferation. This could lead to new methods of treating cancers.
In addition to the possible application set out above, by fabricating nano-features it should be possibly to investigate mechanisms of electron transfer but also spacially resolve such events. This will lead to a greater understanding of the fundamental biology of cancer.
The student will be involved in multi-disciplinary science spanning the bionano-interface. It is expected the student would learn a diverse skill set from biology to chemistry to engineering which will be highly sort after by employers both in the private and public setting.

Funding Notes

If you have a 2i or better honours degree in chemistry, biology or chemical engineering are a UK student and are interested in this project please send your CV to [Email Address Removed] or [Email Address Removed]

References

[1] Paula M. Mendes. Stimuli-responsive surfaces for bio-applications. Chemical Society Reviews, 37, 2008, 2361-2580.
[2] Frankie J. Rawson, David J. Garrett, Donal Leech, Alison J. Downard, Keith H.R. Baronian. Electron transfer from Proteus vulgaris to a covalently assembled, single walled carbon nanotube electrode functionalised with osmium bipyridine complex: Application to a whole cell biosensor. Biosensors and Bioelectronics, 26, 2011, 2383-2389.
[3] Gemma Reguera, Kevin D. McCarthy , Teena Mehta , Julie S. Nicoll, Mark T. Tuominen & Derek R. Lovley. Extracellular electron transfer via microbial nanowires. Nature ,435, 2005, 1098-1101.

Open Days


Project supervisors

Career overview

Professor Paula Mendes is a Professor of Advanced Materials and Nanotechnology in the School of Chemical Engineering at the University of Birmingham. She received her MSc in Chemical Engineering in 1997 and her PhD in 2002, both from the Faculty of Engineering at the University of Porto, Portugal. In 1997, she was awarded a competitive University Fellowship to conduct research in computational chemical engineering at the National Polytechnic Institute of Lorraine (INPL) in Nancy, France. Following her doctoral studies, Professor Mendes undertook post-doctoral research from 2002 to 2004 in the School of Chemistry at the University of Birmingham, UK, and subsequently from 2004 to 2006 at the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), USA, under the supervision of 2016 Nobel Prize winner in Chemistry, Professor Sir Fraser Stoddart FRS. She began her academic career at the University of Birmingham in 2006 as an academic fellow and was promoted to Senior Lecturer in 2011, and then to Professor of Advanced Materials and Nanotechnology in 2013. Additionally, she served as a Visiting Professor at the University of Washington''s Department of Bioengineering in the USA from September 2015 to July 2018. Professor Mendes leads the Mendes Research Group, which focuses on interdisciplinary research in nanoscience and nanotechnology, developing methods to control the structure and functionality of materials at the molecular and nanometer scale. Her research addresses fundamental scientific questions and aims to create innovative technologies to tackle challenges in biofouling, on-demand biosensing, and molecular diagnostics, ultimately benefiting human health. She is also a member of the Healthcare Technologies Institute (HTI), collaborating with over 70 academics to advance new technologies and treatments for improved tissue healing and rehabilitation. Her contributions to the field have been recognised through numerous awards, including the European Research Council (ERC) Advanced Grant in 2024, the 2021 Institution of Chemical Engineers (IChemE) Sharma Medal, and the 2019 Women in Tech Academic Award. Professor Mendes has authored over 100 manuscripts, holds four patents, and has received prestigious research funding, including an Engineering and Physical Sciences Research Council (EPSRC) Fellowship and ERC grants. She serves as an editor for several scientific journals and is actively involved in the Institution of Chemical Engineers Research and Innovation Community of Practice.


Research interests

Professor Mendes'' research focuses on advanced materials and nanotechnology, particularly at the intersection of engineering, chemistry, and biology. She leads the Mendes Research Group, which conducts interdisciplinary research in nanoscience and nanotechnology, developing methods to control the structure and functionality of materials at the molecular and nanometer scale. Her research addresses fundamental scientific questions and aims to develop innovative technologies for biofouling prevention, on-demand biosensing, and molecular diagnostics, ultimately benefiting human health. Professor Mendes is involved in the Healthcare Technologies Institute, collaborating with over 70 academics to advance new technologies and treatments for better tissue healing and rehabilitation. Her pioneering work includes the use of electrically switchable oligopeptides for controlling biological interactions and the development of molecular-based biosensors applicable in various fields, including cell therapy bioprocessing and cancer diagnosis. She has authored over 100 manuscripts and holds multiple patents, receiving recognition through prestigious research grants and awards.

View Professor Paula Mendes's profile