Visualising genome rearrangements during maturation of immune cell precursors. at University of Leeds on FindAPhD.com

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Dr R Tuma, Dr J Boyes No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

Essential processes such as transcription and recombination critically rely on dynamic interactions between DNA sequences that are many kilobases apart. Currently, studies of these interactions are limited since the tools are lacking. This project aims to combine CRISPR proteins that can be programmed to bind any DNA sequence of choice with cutting-edge single molecule imaging tools. CRISPR proteins will be labelled and used to probe the dynamics and regulation of long range DNA interactions during V(D)J recombination. These studies are central to determining how the correct pieces of DNA are brought together for recombination and thus how leukaemogenic translocations and cancer are prevented.

Funding Notes

BBSRC White Rose Mechanistic Biology DTP 4 year studentship.
Studentships covers UK/EU fees and stipend (c.£14,296) for 4 years to start in Oct 2017. Applicants should have/be expecting at least a 2.1 Hons. degree in a relevant subject. EU candidates require 3 years of UK residency in order to receive full studentship.
Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process and the projects selected by the successful candidates will be funded.
There are 2 stages to the application process. Please see our website for more information: http://www.fbs.leeds.ac.uk/postgraduate/phdopportunities.php

References

Supervisors' web sites:
http://www.astbury.leeds.ac.uk/people/staffpage.php?StaffID=RT

School web site:
http://www.fbs.leeds.ac.uk/gradschool/research/index.php

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Visualising genome rearrangements during maturation of immune cell precursors.

University of Leeds Faculty of Biological Sciences