Laser-induced nucleation for control of crystal properties in continuous manufacture of pharmaceuticals

Obtaining the desired polymorphic form of a drug compound is crucial for pharmaceutical manufacturing since it affects properties related to the performance of the drug. Laser-induced nucleation has the potential for use in controlling the crystallization process to yield specific crystal polymorphic form. The mechanism for this effect is not well-understood and there has been little investigation of its application to continuous manufacture of crystalline products. In this project we aim to use laser-induced nucleation to achieve precise control over the nucleation and growth of particles via crystallization under continuous flow. to obtain ‘perfect particles’ for different applications.
This project is a four-year studentship as part of the Doctoral Training Centre (DTC) in Continuous Manufacturing and Crystallisation (http://its-ewds1.ds.strath.ac.uk/cmac/Home.aspx). This provides the opportunity to work a problem of fundamental scientific interest within a programme of research that is aligned to the needs of industry. The student will receive formal training in a wide range of aspects of continuous manufacturing and crystallization as well as optical measurement techniques.