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Prof S Duckett
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About the Project
An Engineering and Physical Sciences Research Council (EPSRC) Industrial CASE studentship with GlaxoSmithKline is available to explore a development in NMR spectroscopy that improves the techniques sensitivity by three orders of magnitude.
Measurements in York have already used it to demonstrate that the acquisition of data in seconds that would take approximately three months to collect with conventional techniques. This studentship will provide opportunities to develop this NMR based procedure to monitor metabolites in plasma. It will seek to quantify them and link their presence to disease. The project will feature a range of methods that include the synthesis of 13C labelled pharmaceuticals, some metal based catalysts and both NMR and MRI type measurements. A perspective on this work can be found at http://www.york.ac.uk/chym/.
The student will be located in the newly opened Centre for Hyperpolarisation in Magnetic Resonance. The Centre for Hyperpolarisation in Magnetic Resonance (CHyM) is a joint research centre created by the Department of Chemistry and the Department of Psychology at the University of York. CHyM is associated with the Hull York Medical School, the York Neuroimaging Centre and the Department of Biology.
The aim of the Centre is to bring together research scientists to explore the fundamental processes that underpin hyperpolarisation techniques. These methods have the potential to address the sensitivity issues associated with NMR and MRI. In NMR applications these can be used to detect low-concentration, short-lived chemical intermediates and offer significant opportunities in the fields of heterogeneous and homogeneous catalysis. In MRI applications, they have the potential to revolutionise clinical imaging.
The Centre has recieved high levels of support from the Wellcome Trust, Wolfson Foundation, University of York, EPSRC and industrial collaborators totalling in excess of £11m, in order to archive these aims. The Centre’s research has resulted in many high-impact publications.
The Centre is based in a purpose-built facility on the York Science Park and has a dedicated chemical laboratory, biological preparation areas and an instrument design area. The Centre also houses four state-of-the-art high resolution NMR spectrometers, and a 7 T pre-clinical MRI scanner, all of which are equipped for hyperpolarisation research.
For more details about the PhD project, contact Professor Duckett [Email Address Removed].
The Department of Chemistry holds an Athena SWAN Gold Award and is committed to supporting equality and diversity for all staff and students.
Measurements in York have already used it to demonstrate that the acquisition of data in seconds that would take approximately three months to collect with conventional techniques. This studentship will provide opportunities to develop this NMR based procedure to monitor metabolites in plasma. It will seek to quantify them and link their presence to disease. The project will feature a range of methods that include the synthesis of 13C labelled pharmaceuticals, some metal based catalysts and both NMR and MRI type measurements. A perspective on this work can be found at http://www.york.ac.uk/chym/.
The student will be located in the newly opened Centre for Hyperpolarisation in Magnetic Resonance. The Centre for Hyperpolarisation in Magnetic Resonance (CHyM) is a joint research centre created by the Department of Chemistry and the Department of Psychology at the University of York. CHyM is associated with the Hull York Medical School, the York Neuroimaging Centre and the Department of Biology.
The aim of the Centre is to bring together research scientists to explore the fundamental processes that underpin hyperpolarisation techniques. These methods have the potential to address the sensitivity issues associated with NMR and MRI. In NMR applications these can be used to detect low-concentration, short-lived chemical intermediates and offer significant opportunities in the fields of heterogeneous and homogeneous catalysis. In MRI applications, they have the potential to revolutionise clinical imaging.
The Centre has recieved high levels of support from the Wellcome Trust, Wolfson Foundation, University of York, EPSRC and industrial collaborators totalling in excess of £11m, in order to archive these aims. The Centre’s research has resulted in many high-impact publications.
The Centre is based in a purpose-built facility on the York Science Park and has a dedicated chemical laboratory, biological preparation areas and an instrument design area. The Centre also houses four state-of-the-art high resolution NMR spectrometers, and a 7 T pre-clinical MRI scanner, all of which are equipped for hyperpolarisation research.
For more details about the PhD project, contact Professor Duckett [Email Address Removed].
The Department of Chemistry holds an Athena SWAN Gold Award and is committed to supporting equality and diversity for all staff and students.
Funding Notes
This project is funded by an Engineering and Physical Sciences Research Council (EPSRC) Industrial CASE studentship with GlaxoSmithKline (GSK) which will cover full tuition fees and a stipend to a UK student. Applications are also accepted for the project from students from any country WHO CAN FULLY FUND THEIR OWN STUDIES.
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