We have 16 University of Leicester, Department of Genetics and Genome Biology PhD Projects, Programmes & Scholarships

Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more

Supervisors: Dr C Jenul, Prof D Jones

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

University of Leicester Department of Genetics and Genome Biology

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

Supervisors: Dr B Warren, Dr E Rosato, Dr R Feuda

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Epigenetic ageing and calorie restriction in an insect model system

University of Leicester Department of Genetics and Genome Biology

This project will help establish an insect model for epigenetic ageing, by analysing the effects of calorie restriction on chronological and epigenetic aging in an important insect model, Nasonia vitripennis, extending our discovery of an epigenetic clock in Nasonia. . Read more

Supervisors: Prof E Mallon, Dr K Chen

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Investigating the role of SUMOylation in meiotic recombination and chromosome segregation in Arabidopsis

University of Leicester Department of Genetics and Genome Biology

Post-translational modifications of proteins such as phosphorylation, methylation and acetylation have been extensively studied in eukaryotes and now the Small Ubiquitin modifier (SUMO) is gaining attention for its importance in fundamental biological roles. Read more

Supervisors: Dr J Higgins, Dr D Guttery

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Unlocking the genetic potential of barley by modulating recombination

University of Leicester Department of Genetics and Genome Biology

Barley is a major worldwide crop used for malting and animal feed. However, breeding new varieties is constrained by the frequency of genetic crossovers (1-3 crossovers per chromosome pair) and their distribution (biased towards the chromosome ends) that underpin crop improvement1,2. Read more

Supervisors: Dr J Higgins, Dr D Guttery

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Enhancing meiotic recombination in wheat by modulating RECQ helicases

University of Leicester Department of Genetics and Genome Biology

Wheat accounts for 20% of the calories and protein consumed by humans and is the largest crop in the UK, but yields have plateaued and are susceptible to decline due to extreme weather conditions. Read more

Supervisors: Dr J Higgins, Dr D Guttery

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Dissecting the interplay of extracellular vesicle signalling and tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology

L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more

Supervisor: Prof F Giorgini

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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The Evolution of Vision in Mosquitoes

University of Leicester Department of Genetics and Genome Biology

Background . Due to their capacity to transmit viruses such as Zika and parasites like Plasmodium (the causative agent of malaria), mosquitos are regarded by the World Health Organization as one of the most lethal organisms on our planet (WHO | Global vector control response 2017–2030, 2020). Read more

Supervisors: Dr R Feuda, Dr E Rosato, Dr B Warren

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Identifying the neurogenetic network underlying visually-driven sleep

University of Leicester Department of Genetics and Genome Biology

General background. Sleep is a behavioural quiescence widely observed in the animal kingdom. During sleep, an animal’s motor activity, as well as their responsiveness to environmental stimuli, are largely reduced. Read more

Supervisors: Dr K Chen, Dr R Feuda

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Impact of Hypermutability and Restriction-Modification by Campylobacter jejuni, a foodborne pathogen, on Bacteriophage Control Measures

University of Leicester Department of Genetics and Genome Biology

Campylobacter jejuni is a major foodborne pathogen responsible for thousands of cases gastroenteritis every year. The major source of infections by this bacterial pathogen is contaminated poultry products. Read more

Supervisors: Prof C D Bayliss, Prof M Clokie

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Early life environment changes how organisms age.

University of Leicester Department of Genetics and Genome Biology

This project will help understand why organisms age differently by establishing the effect of early life environments on epigenetic ageing in the model insect, Nasonia vitripennis. Read more

Supervisor: Prof E Mallon

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genomics of malignant pleural mesothelioma

University of Leicester Department of Genetics and Genome Biology

Malignant pleural mesothelioma is a rare, incurable cancer that carries a dismal prognosis. Its incidence is increasing globally despite its primary cause, asbestos exposure, having been known for over 50 years. Read more

Supervisor: Prof E Hollox

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploiting raptor genome sequences to combat wildlife crime

University of Leicester Department of Genetics and Genome Biology

Birds of prey have suffered persecution for centuries through trapping, shooting, poisoning and theft from the wild to meet the demand from egg collectors and falconers; they were also amongst the earliest beneficiaries of DNA testing in wildlife forensics. Read more

Supervisor: Dr C May

Year round applications PhD Research Project Self-Funded PhD Students Only

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Agricultural genomics, chromosomes, genome and repetitive sequence evolution in crops, farm animals, models and wild relatives

University of Leicester Department of Genetics and Genome Biology

In this project, you will investigate the large-scale organization of an agricultural species and its wild relatives. We will use genomic data from DNA sequencing, including methylation where appropriate. Read more

Supervisor: Prof P HESLOP-HARRISON

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Functional effects of variable number tandem repeat expansions in idiopathic pulmonary fibrosis

University of Leicester Department of Genetics and Genome Biology

Research Group: Human & Medical Genetics

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by the formation of scar tissue in the lungs. Read more

Supervisor: Prof E Hollox

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 16 University of Leicester, Department of Genetics and Genome Biology PhD Projects, Programmes & Scholarships

University of Leicester, Department of Genetics and Genome Biology PhD Projects, Programmes & Scholarships

We have 16 University of Leicester, Department of Genetics and Genome Biology PhD Projects, Programmes & Scholarships

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