Mathematical Modelling of the Circadian Ca2+ Signalling Network (with Dr Jorge Goncalves, Department of Engineering, University of Cambridge)

As part of our systems approach we are looking to appoint a graduate with a degree in a mathematical subject to model the role of a Ca2+ switch in the circadian oscillator of plants. We wish to use mathematical models to describe likely biological mechanisms and roles for a switch in the oscillator required for daily timing. We have focused on the use of linear systems to describe circadian systems (Herrero et al., (2012) Plant Cell 24, 428-443; Dalchau et al (2010) PNAS 107, 13171-13176) and you will use linear systems to dissect further the role of the Ca2+ switch in the circadian system. In collaboration with Dr J Gonçalves, we develop new approaches to use the power of linear systems to analyse biological datasets and develop new understanding.

Full training in biological approaches and techniques will by provide by Dr Alex Webb in Plant Sciences whilst mathematical training will by provided by Dr Jorge Gonçalves in Engineering. This is an exciting opportunity for a mathematically trained graduate to make the transition to systems biology.