About the Project
We wish to recruit an enthusiastic and highly motivated PhD student for the laboratory of Dr Matthias Trost. The applicant will be working in a project studying a novel cell signalling pathway in macrophages in disease-relevant models.
Our lab uses state-of-the-art proteomics, cell biology and biochemistry technologies and applies them to relevant biological questions. We have in the recent past published important papers for the understanding of molecular mechanisms in macrophage biology and disease models (Trost et al, 2009, Immunity; Lai et al, 2015, EMBO Journal; Guo et al, submitted). Moreover, we have developed exciting new mass spectrometry technologies that helped advance the ubiquitylation and phosphorylation fields (Ritorto et al, Nature Communications, 2014; Ritorto et al, J Proteome Res, 2013) and we have several new unpublished technologies.
Applicants should hold (or expect to obtain) a minimum upper-second honours degree (or equivalent) in chemistry, biology, biochemistry or a related field. In addition, the candidate should be able to work independently and thrive in a multi-disciplinary research environment. Strong interpersonal and communication skills are essential as is the ability to work as part of a team. Previous experience in proteomics, analytical chemistry, chromatography, biochemistry or cell biology would be an advantage, but is not essential.
For informal enquiries please contact Matthias Trost ([Email Address Removed]).
The College of Life Sciences has developed into one of the world’s leading centres of quantitative mass spectrometry with currently 22 Orbitrap mass spectrometers present in the building, while the Unit facility is equipped with eight state-of-the art-mass spectrometers, which include three Orbitraps (one Fusion, two Velos Pro), a Velos Pro ETD, a QTrap5500 and two UltrafleXtreme MALDI TOF mass spectrometers. Please consult the Unit website for further details of its research programmes (http://www.ppu.mrc.ac.uk).
Funding Notes
The 4-year full-time BBSRC CASE studentship provides full support for UK/EU tuition fees and an annual tax-free stipend of £16,363. The project is available immediately and due to commence latest September 2016. Due to the nature of the funding it is only open to UK nationals and EU nationals resident in the UK for three years prior to the start of the studentship.
References
Ritorto, M. S., Ewan, R., Perez-Oliva, A. B., Knebel, A., Buhrlage, S. J., Wightman, M., Kelly, S. M., Wood, N. T., Virdee, S., Gray, N. S., Morrice, N. A., Alessi, D. R. and Trost, M. (2014). Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun 5, pp. 4763
Ritorto, M. S., Cook, K., Tyagi, K., Pedrioli, P. G. and Trost, M. (2013). Hydrophilic Strong Anion Exchange (hSAX) Chromatography for Highly Orthogonal Peptide Separation of Complex Proteomes. J Proteome Res 12, pp. 2449-2457