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| Gene regulation and disease. | ||||||||||||||||||
The correct development and functioning of all organisms requires the coordination of specific gene expression profiles during the commitment of stem cells and the appropriate control of gene expression in differentiated cells. Many human diseases such as cardiac hypertrophy, vascular proliferative disease and cancer result from inappropriate expression of specific genes. We have previously shown that the transcription factor REST, which is expressed in stem cells and many different tissues plays significant roles in a variety of disease states (see Ooi and Wood, 2007). Loss of REST function results in cardiac hypertrophy, vascular smooth muscle proliferation and colon cancer. In neurons, increased REST expression is associated with Huntington’s disease, global cerebral ischemia and epilepsy. The main aim of our group is to understand the molecular mechanisms important in controlling gene expression in differentiation and disease states as cancer, cardiovascular disease and epilepsy. To achieve these aims we use a combination of biochemical and genetic approaches (including protein:protein interactions, microarray analysis, microRNA assays and cellular signalling cascades). Ooi and Wood (2007), Nature Reviews Genetics, 8, 544-554. http://www.nature.com/nrg/journal/v8/n7/full/nrg2100.html Funding Notes Applications are welcome at any time, but deadlines exist for some awards (see http://www.fbs.leeds.ac.uk/gradschool/research/PhDStudentships.htm). Offers are made to the most able students as soon as possible. For more information see: http://www.fbs.leeds.ac.uk/People/staffprofile.php?staff=ICW Ooi L. Wood IC.(2008), Biochem J. 2008 414, 327-41. http://www.biochemj.org/bj/414/0327/bj4140327.htm Ooi L. and Wood IC. (2007), Nature Reviews Genetics, 8, 544-554. http://www.nature.com/nrg/journal/v8/n7/full/nrg2100.html Bingham AJ, Ooi L, Kozera L, White E, Wood IC. (2007) Mol Cell Biol. 27, 4082–4092. http://mcb.asm.org/cgi/content/full/27/11/4082?view=long&pmid=17371849 Bingham AJ, Ooi L, Wood IC.(2006) Biochem Soc Trans. 34, 138-40. http://www.biochemsoctrans.org/bst/034/1138/bst0341138.htm Cheong A, Wood IC, Beech DJ. (2006) Cell Cycle 5, 129-31 http://www.landesbioscience.com/journals/cc/abstract.php?id=2310 Cheong A, Bingham AJ, Li J, Kumar B, Sukumar P, Munsch C, Buckley NJ, Neylon CB, Porter KE, Beech DJ, Wood IC. (2005) Molecular Cell 20, 45-52 http://www.molecule.org/content/article/abstract?uid=PIIS1097276505015947 |
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Research Assessment Exercise (RAE) 2008 Results
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