Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. WNT signalling is a key pathway controlling morphogenesis in embryos and it has been shown that perturbations of this pathway promote cancer progression.
Applicants are invited for a new self-funded PhD studentship to study the molecular mechanisms of cardiac fibrosis. Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease.
Mechanical forces are involved in many physiological processes. While most of the current work in mechanotransduction has focused on the function of focal adhesion proteins and the actin cytoskeleton, the mechanical role of intracellular and nuclear proteins remains rather elusive.