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als PhD Projects, Programmes & Scholarships

We have 15 als PhD Projects, Programmes & Scholarships

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We have 15 als PhD Projects, Programmes & Scholarships

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Investigating the role of SOD1 in sporadic Motor Neuron Disease patients using structural proteomics

Background. Motor Neuron Disease/Amyotrophic lateral sclerosis (ALS) is a complex neurological disorder characterised by the progressive degeneration of motor neurons that is thought to be caused by mitochondrial dysfunction leading to oxidative stress and neuroinflammation. Read more

Unravelling the role of interneurons in Amyotrophic Lateral Sclerosis

In ALS, motoneuron degeneration leads to muscle paralysis. Motoneurons are the final output of the brain since they directly connect to muscles, but their synchronized activation depends on networks of spinal interneurons. Read more

Self funded BMS Project: Innate immune responses in aymotrophic lateral sclerosis and frontotemporal dementia.

Applications accepted for PhD Only. Neurons express an innate immune response cascade to regulate synaptic homeostasis. We have identified activation of components of this innate immune cascade in response to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia associated (FTD) mutations. Read more

Synaptic dysfunction in Drosophila models of neurodegenerative diseases

Almost a million of people in the UK suffer from neurodegenerative disorders. Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD) are the most common causes of neurodegenerative dementias. Read more

The potential of circulating diagnostic and prognostic biomarkers in neurodegenerative and neuromuscular diseases

  Research Group: Medicine
Age-associated neurodegenerative diseases, including dementias, such as Alzheimer’s disease (AD) and Frontotemporal dementia (FTD), and clinically overlapping conditions such as Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS), are increasing, in line with the aging worldwide population1. Read more

Tripartite synapses – a weak link in Motor Neuron Disease?

Neurons transmit information via trillions of synapses found throughout the nervous system. Some synapses receive contacts from non-neuronal cells, called astrocytes, which ‘listen in’ on neuronal communication and signal back to modulate neural activity. Read more

Decoding Speech using Invasive Brain-Computer Interfaces

For individuals who have impaired speech or complete loss of speech as a result of neurodegenerative diseases such as motor neurone disease (MND) or amyotrophic lateral sclerosis (ALS), there is an urgent need to develop revolutionary technologies using the latest advances in automatic speech recognition (ASR) and brain signal processing (BSP). Read more

Neurodegenerative disorders

We are currently looking for a PhD candidate to work on the following projects. Understanding enzymes linked to neurodegeneration and antiviral defence. Read more

The cellular response to stress: roles in disease and ageing

All living organisms need to adapt to their environment in order to survive and reproduce. They are subjected to many stresses including altered oxygen levels, heat or cold, irradiation, infection and injury. Read more
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