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amyloid PhD Projects, Programmes & Scholarships
We have 16 amyloid PhD Projects, Programmes & Scholarships
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Computer simulation of metal-amyloid interaction and its role in plaque formation
Alzheimer’s disease is one of the greatest healthcare challenges facing 21st century society. AD is associated with formation of fibrils and plaques in brain tissue that impair proper functioning of neurons. Read more
Nanoinjection: a novel single molecule technique to study alpha-synuclein amyloid toxicity inside neurons
Intraneuronal inclusions known as Lewy bodies are a hallmark of Parkinson’s disease. Amyloid fibrils formed by the misfolding of alpha-synuclein are the principal component of Lewy Bodies. Read more
Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist. Read more
Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimers disease
Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease. Read more
Screening of chemical libraries using iPS models for investigating the role of prion protein in Alzheimer’s disease
Background. AD has been identified as a protein misfolding disease (proteopathy). The disease is caused by accumulation of two major amyloids. Read more
Proteomic response to amyloid oligomers within a 3D Parkinson's disease model
Parkinson's disease (PD) is a progressive neurodegenerative condition that worsens as cells within the brain region known as the substantia nigra are lost over time. Read more
Next Generation High-Speed Atomic Force Microscopy in the Wolfson Imaging Facility
Research Group:
School of Physics and Astronomy
To better understand diseases and to develop new treatment options, we need to understand very fast biological processes occurring at single molecule level. Read more
4-year PhD Studentship: The molecular mechanisms of transcranial ultrasound neuromodulation as a novel therapeutic intervention in neurological disorders
Neural activity follows repetitive, rhythmic patterns, caused by oscillations in membrane potentials or synchronised action potential firing. Read more
Cell models to investigate mechanisms of disease; the role of redox in neurodevelopment and neurodegeneration
We use cell models of neurodevelopment and neurodegeneration to study the mechanisms that underpin diseases like schizophrenia and dementia. Read more
Lysozyme encapsulated gold nanoclusters – a new therapeutic agent for Alzheimer’s disease
Alzheimer’s disease (AD) has become a major medical challenge with huge social and economic consequences due to increasing life expectancy. Read more
Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders
Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more
4-year PhD Studentship: Investigating the relationship and modelling the impact of neuroinflammation on cerebral vascular function in dementia using novel 3D models of the cerebral vasculature
Reduced blood flow and a breakdown of the protective blood-brain barrier (BBB) are major contributors to the development of cognitive decline and disease pathology in the early stages of dementia [1]. Read more
4-year PhD Studentship: Novel immunological mechanisms and treatment targets for depression: evidence from randomised designs
Low-grade systemic inflammation represents one promising avenue for new mechanistic explanation and therapeutic development for depression, but success of future trials of immunotherapies will depend of optimum target selection based on evidence of causality. Read more
Understanding how altered GABA signalling in the brain's master clock contributes to circadian rhythm disruption in Alzheimer's disease
Our circadian clock is one of the most important timing systems in our body, ensuring that neuronal activity throughout our CNS is appropriately aligned with our homeostatic, physiological, and behavioural needs across the day. Read more
Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain. Read more
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