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amyloid PhD Projects, Programs & Scholarships

We have 19 amyloid PhD Projects, Programs & Scholarships

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  An integrated approach to the study of cellular interactions with amyloid
University of Leeds Faculty of Biological Sciences
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round
The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
Details
Type/Funding
  Computer simulation of metal-amyloid interaction and its role in plaque formation
Cardiff University Cardiff School of Chemistry
  Dr J Platts
Applications accepted all year round
Alzheimer’s disease is one of the greatest healthcare challenges facing 21st century society. AD is associated with formation of fibrils and plaques in brain tissue that impair proper functioning of neurons.
Details
Type/Funding
  Investigating the links between osteoporosis & Alzheimer’s disease – effects of β-amyloid upon the mechanical set-point in bone
Queen Mary University of London Institute of Dentistry
  Dr S McArthur, Dr SCF Rawlinson
Applications accepted all year round
Background. Individuals with Alzheimer’s disease are more likely to suffer from osteoporosis (the loss of bone mass and strength) than age-matched individuals; significantly contributing to the frailty associated with dementia.
Details
Type/Funding
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
University of Manchester Faculty of Biology, Medicine and Health
  Dr M Harte, Prof J Neill
Applications accepted all year round
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
Details
Type/Funding
  Cryo-EM structural analysis of amyloid fibrils
University of Ulm Institute of Protein Biochemistry
  Prof M Fändrich, Dr M Schmidt
Applications accepted all year round
The Institute of Protein Biochemistry at Ulm University, Germany, investigates the molecular basis of amyloid diseases, such as Alzheimer’s disease and systemic amyloidosis.
Details
Type/Funding
  Protein Misfolding and the Molecular Basis of Alzheimer’s Disease
Queen Mary University of London School of Biological & Chemical Sciences
  Dr J Viles
Applications accepted all year round
Background. World-wide one in three people over the age of 65 will die with Alzheimer’s Disease (AD). The disease is characterised by deposits of amyloid plaques and fibrils of amyloid-beta peptide (Ab) are their main constituent.
Details
Type/Funding
  Inhibiting amyloid development using natural compounds: a molecular dynamics study
University of Strathclyde Department of Chemical and Process Engineering
  Dr P Mulheran, Dr V A Ferro
Applications accepted all year round
Amyloid fibrils are highly ordered protein aggregates associated with many neurodegenerative diseases such as Alzheimer’s. Flavanoids, which are polyphenols such as curcumin present in the human diet, have been shown to inhibit fibril formation in tau protein which is abundant in neurons.
Details
Type/Funding
  The molecular basis of a genetic susceptibility gene in Alzheimer’s disease: the case of cystatin C
University of Sheffield Department of Molecular Biology and Biotechnology
  Dr R Staniforth
Applications accepted all year round
Degenerative diseases associated with ageing occur sporadically and are associated with the misfolding and aggregation of a number of proteins in vivo.
Details
Type/Funding
  Investigating the molecular mechanisms and consequences of ANP aggregation for cardiovascular disease; a computational and experimental approach
University of Liverpool Institute of Integrative Biology
  Dr J Madine, Dr D J Rigden, Dr M Winn
Applications accepted all year round
Atrial natriuretic peptide (ANP) is a cardiovascular hormone synthesised and secreted by myocytes in the atrial wall where it regulates atrial blood volume and vasodilation.
Details
Type/Funding
  Does a common aetiology between Alzheimer’s disease and osteoporosis exist?
University of Southampton Biological Sciences
  Dr C Clarkin, Dr K Deinhardt
Application Deadline: 12 April 2019
Bone is highly innervated with bone mass and bone homeostasis regulated by central cues and transmitted mainly via the sympathetic nervous system.
Details
Type/Funding
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