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We have 16 amyloid PhD Projects, Programmes & Scholarships

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amyloid PhD Projects, Programmes & Scholarships

We have 16 amyloid PhD Projects, Programmes & Scholarships

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Investigating the links between β-amyloid, osteoporosis and frailty in Alzheimer’s disease

Background. Individuals with Alzheimer’s disease are more likely to suffer from osteoporosis (the loss of bone mass and strength) than age-matched individuals1, significantly contributing to the frailty associated with dementia. Read more

PhD in Chemistry: Computer simulation of metal-amyloid interaction and its role in plaque formation

Alzheimer’s disease is one of the greatest healthcare challenges facing 21st century society. AD is associated with formation of fibrils and plaques in brain tissue that impair proper functioning of neurons. Read more

Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist. Read more

Seeing inside the brain of Alzheimer’s disease by cryoET

The aim of this PhD project is to determine the in situ 3D molecular structures associated with AD to understand disease mechanisms and molecular pathways that can lead to the rational design of a mechanism-based therapy. Read more

Learning a universal biomolecular force field

Molecular dynamics has been successful in obtaining biological insights by simulating the motion of biomolecules. Increases in compute power mean that simulations will soon reach the time scales on which much of biology happens. Read more

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