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amyloid PhD Projects, Programmes & Scholarships
We have 16 amyloid PhD Projects, Programmes & Scholarships
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Alpha-synuclein amyloid in Parkinson's disease: using Nanoinjection as a tool to study alpha-synuclein amyloid toxicity inside neurons
Intraneuronal inclusions known as Lewy bodies are a hallmark of Parkinson’s disease. Amyloid fibrils formed by the misfolding of alpha-synuclein are the principal component of Lewy Bodies. Read more
Investigating the links between β-amyloid, osteoporosis and frailty in Alzheimer’s disease
Background. Individuals with Alzheimer’s disease are more likely to suffer from osteoporosis (the loss of bone mass and strength) than age-matched individuals1, significantly contributing to the frailty associated with dementia. Read more
Full exploitation of amyloid PET-MR data for dementia research
Simultaneous PET-MR data acquisition using amyloid radiotracers has utility for future clinical studies such as the development of novel therapeutic interventions for dementia. Read more
Drug discovery for amyloid plaques based neurodegenerative disorders (ref: SF22/HLS/APP/MEERA)
Alzheimer’s disease (AD) followed by Parkinson’s Disease (PD) are the two most prominent causes of dementia that poses a huge health burden in an increasingly ageing population worldwide. Read more
PhD in Chemistry: Computer simulation of metal-amyloid interaction and its role in plaque formation
Alzheimer’s disease is one of the greatest healthcare challenges facing 21st century society. AD is associated with formation of fibrils and plaques in brain tissue that impair proper functioning of neurons. Read more
Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist. Read more
Epigenetic regulation of microglial gene expression in Alzheimer’s disease
Neuroinflammation is a prominent event Alzheimer’s disease (AD) pathogenesis driven by activation of microglia, the brains resident immune cells. Read more
Seeing inside the brain of Alzheimer’s disease by cryoET
The aim of this PhD project is to determine the in situ 3D molecular structures associated with AD to understand disease mechanisms and molecular pathways that can lead to the rational design of a mechanism-based therapy. Read more
Cryo-EM studies of amyloids in neurodegeneration
Our group develops new algorithms for cryo-EM structure determination and implements these in the popular image processing software RELION. Read more
Learning a universal biomolecular force field
Molecular dynamics has been successful in obtaining biological insights by simulating the motion of biomolecules. Increases in compute power mean that simulations will soon reach the time scales on which much of biology happens. Read more
Characterising a novel neuroimmune pathway to treat neurodegenerative disease. MRC GW4 BioMed DTP PhD studentship 2024/25 Entry, PhD in Clinical & Biomedical Sciences
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders
The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
Feeding microbes to protect the brain: does the gut microbiota mediate the risk-reducing effects of a healthy diet on Alzheimer’s disease?
Background. Ways of reducing the risk of developing Alzheimer’s disease (AD) and other dementias are critically needed, given the almost total lack of truly effective therapeutic options, even despite newer anti-amyloid drugs1. Read more
Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain. Read more
Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
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