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We have 15 angiogenesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
angiogenesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 15 angiogenesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Transcriptional control of vascular development
Sprouting of new capillaries from pre-existing vessels (angiogenesis) promotes the formation of almost all blood vessels during development, growth and tissue regeneration. Read more
Genetics: Unravelling the Norrin/beta-catenin signaling pathway and its role in retinal angiogenesis and blindness
Our previous work on the genetic analysis of individuals with the inherited retinal disease Familial Exudative Vitreoretinopathy (FEVR), has helped identify a new angiogenesis pathway, the Norrin/beta-catenin pathway. Read more
Dermal delivery of hydrogen sulphide donors in the treatment of diabetic pressure ulcers
Diabetic wounds associated with pressure ulcers are a worldwide concern affecting around 26 million patients annually with 15-25% of diabetic patients developing foot ulcer during their lifetime [1]. Read more
Using zebrafish models to investigate cerebral arteriovenous malformations
Cerebral Arteriovenous Malformations (cAVM) relate to a spectrum of conditions associated with blood vessel abnormalities of the brain [1]. Read more
Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer
Research Group:
Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more
Characterization of molecular and cellular mechanisms implicated in evasion of anti-VEGF therapies by human brain tumours
Angiogenesis is a biological process by which new capillaries are formed from pre-existing vessels. It is well established that brain tumour growth depends on angiogenesis. Read more
Interactions between dietary isothiocyanates and anti-cancer drug sorafenib in breast cancer (BAOY_U23MED204350)
High consumption of cruciferous vegetables can reduce the risk of cancer. Read more
Countering the proteinase-activated receptor 1 (PAR-1) pro-tumour phenotype using a novel nanotherapeutic approach
Proteinase-activated receptor 1 (PAR1) is a G-protein coupled receptor (GPCR) expressed on a number of cell types, and is activated by serine proteases such as thrombin, plasmin and activated protein C. Read more
Investigating the mechanistic effects of nutraceuticals on myoblast proliferation and differentiation for healthy muscle ageing and improved performance
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Define the underlying mechanism of action of fertilised egg yolk as a nutritional supplement on muscle using an in vitro model and -omics technologies. Read more
The Role of Fusion Proteins in Salivary Gland Tumourigenesis
Salivary gland tumours are uncommon but have a varied and complex pattern of histopathological features. Read more
Understanding transcription factor complexes controlling endothelial cell quiescence and escape from quiescence
Endothelial cell proliferation and lymphatic cell proliferation is initiated during angiogenesis and lymphangiogenesis respectively and are both regulated by the VEGF signalling pathway. With some exceptions, endothelial and lymphatic cells in healthy individuals are quiescent and do not proliferate. Read more
Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
Research Group:
Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
Understanding transcription factor complexes in endothelial quiescence
Endothelial cell proliferation and lymphatic cell proliferation known as angiogenesis and lymphangiogenesis respectively are both regulated by ligands in the VEGF signalling pathway. Read more
SELF-FUNDING MSc BY RESEARCH PROJECT: Bioengineering platelets for Blood Transfusions
Platelets are essential elements of the blood responsible for primary haemostasis. It is clear, however, that their role is much wider than just this, playing a critical element in aspects of angiogenesis, wound healing, tissue regeneration, tumour growth and metastasis and inflammation. Read more
Inorganic chaperones fused to fungal derived chemotherapeutic agents for the treatment of neuroblastoma
This is a unique and cutting-edge PhD research opportunity in the multidisciplinary field of nanotechnology for a student with a strong background in chemistry / biochemistry interested in applying knowledge and developing drugs and drug delivery systems for cancer chemotherapy. Read more
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