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We have 15 angiogenesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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angiogenesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 15 angiogenesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Transcriptional control of vascular development

Sprouting of new capillaries from pre-existing vessels (angiogenesis) promotes the formation of almost all blood vessels during development, growth and tissue regeneration. Read more

Genetics: Unravelling the Norrin/beta-catenin signaling pathway and its role in retinal angiogenesis and blindness

Our previous work on the genetic analysis of individuals with the inherited retinal disease Familial Exudative Vitreoretinopathy (FEVR), has helped identify a new angiogenesis pathway, the Norrin/beta-catenin pathway. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Countering the proteinase-activated receptor 1 (PAR-1) pro-tumour phenotype using a novel nanotherapeutic approach

Proteinase-activated receptor 1 (PAR1) is a G-protein coupled receptor (GPCR) expressed on a number of cell types, and is activated by serine proteases such as thrombin, plasmin and activated protein C. Read more

Understanding transcription factor complexes controlling endothelial cell quiescence and escape from quiescence

Endothelial cell proliferation and lymphatic cell proliferation is initiated during angiogenesis and lymphangiogenesis respectively and are both regulated by the VEGF signalling pathway. With some exceptions, endothelial and lymphatic cells in healthy individuals are quiescent and do not proliferate. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

SELF-FUNDING MSc BY RESEARCH PROJECT: Bioengineering platelets for Blood Transfusions

Platelets are essential elements of the blood responsible for primary haemostasis. It is clear, however, that their role is much wider than just this, playing a critical element in aspects of angiogenesis, wound healing, tissue regeneration, tumour growth and metastasis and inflammation. Read more

Inorganic chaperones fused to fungal derived chemotherapeutic agents for the treatment of neuroblastoma

This is a unique and cutting-edge PhD research opportunity in the multidisciplinary field of nanotechnology for a student with a strong background in chemistry / biochemistry interested in applying knowledge and developing drugs and drug delivery systems for cancer chemotherapy. Read more
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