10-20% of worldwide food, from reduced harvest and post-harvest food spoilage, is lost due to fungal contamination. Food loss is due to contamination with mycotoxins such as aflatoxins, which are potent carcinogens and cause severe liver damage.
Our central hypothesis is that antibiotic susceptibility, fitness costs of resistance mutations or plasmids and plasmid transfer rates are affected by the growth rate and physiology of individual cells.
Bacterial infections are becoming harder to treat as antibiotic resistance becomes increasingly prevalent. There is also a lack of drugs in the pipeline to take the place of those that can no longer be used due to resistance and novel therapeutic options are needed.
Programme website. http://inspire-dtp.ac.uk. Project Rationale. Our current NERC study investigates antimicrobial resistance horizontal gene transfer, principally via plasmid conjugation transfer of third generation extended spectrum beta lactamase (ESBL) and fourth generation carbapenemase from E.