Innate antiviral immunity of human embryonic stem cells
Institute of Immunology & Infection Research
Dr S Macias, Dr P De Sousa
13 December 2018
Unlike differentiated or somatic cells, embryonic stem cells (ESCs) are unable to activate their complete innate immune response when confronted with pathogens such as viruses.
Molecular Biology of Antiviral Signalling in the CRISPR system
Biomedical Sciences Research Centre
Prof M F White
7 January 2019
CRISPR is a prokaryotic adaptive immune system that has been harnessed for a wide range of genome engineering, synthetic biology, biotechnology and healthcare applications.
Regulation of the antiviral and neuroinflammatory states of human tissue macrophages
Prof W S James, Dr S Cowley
11 January 2019
The macrophage is an evolutionarily ancient sentinel of the health of all of the body’s tissues. clearing away dead cells and debris; as brain-resident microglia, remodelling defunct neuronal connections; nurturing tissue stem cells; detecting and responding to pathogens.