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antiviral PhD Projects, Programmes & Scholarships
We have 14 antiviral PhD Projects, Programmes & Scholarships
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Genome mining of novel antimicrobial and antiviral natural products from new bacterial strains
Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses. Read more
Development of antiviral peptidomimetic enzyme inhibitors against SARS-CoV-2
Coronaviruses are a large group of viruses that circulate and evolve among various animals. They can cause mild human illnesses such as the common cold or more serious respiratory diseases as seen in the recent outbreaks of SARS (2002), MERS (2012), and the COVID-19 pandemic (2019). Read more
Face off – Dissecting the role of phase separation in viral replication and antiviral responses
Background. The assembly of membraneless organelles is emerging as a fundamental paradigm for many cellular functions. Among these, stress granules (SGs) play a central role in health and disease by concentrating proteins and RNAs, driving adaption to stressful conditions, including viral infection. Read more
Using ex-vivo genetic systems as models to detect genetic susceptibility to co-morbidities in Covid 19 infection, and to test specific anti-inflammatory / antiviral drugs in Covid 19 infection
Research Group:
Chemistry and Biosciences
Research has shown that certain individuals are more susceptible to SARS-CoV-2. Approximately, 20–51% of COVID-19 patients presented with a least one co-morbidity on admission, with diabetes (10–20%) hypertension (10–15%) and other cardiovascular and cerebrovascular diseases (7–40%) being most prevalent. Read more
Phase transitions underlying viral replication: understanding the selectivity of viral replication factories through the lens of biomolecular condensates
There is an urgent need for new drugs to combat pathogenic viruses. Most existing antivirals inhibit virus attachment/entry or target key enzymes, and new antiviral targets are needed to develop novel treatments and counter antiviral resistance. Read more
A biomimetic approach to peroxide-derived polyketide synthesis
Loughborough University has seen 94% of our research impact rated as ‘world-leading’ or ‘internationally excellent’, underlining the wide-ranging positive impacts that our research has on the world (REF, 2021). Read more
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2 – Towards New Antivirals for the Treatment of COVID-19
Fragment-Based Lead Generation of Small Molecule Inhibitors of the Nsp3 Macrodomain in SARS-CoV-2 – Towards New Antivirals for the Treatment of COVID-19. Read more
Generation of human cytomegalovirus-pseudotyped particles and development of systems for the study of viral cell entry mechanisms, neutralizing antibody responses to infection and vaccination, and testing of potential novel therapeutics
Overview. Human cytomegalovirus (HCMV) establishes lifelong infections of the host with >60% infected across the globe. In healthy children and adults HCMV produces mild symptoms like influenza or mononucleosis. Read more
Generation of human cytomegalovirus-pseudotyped particles and development of systems for the study of viral cell entry mechanisms, neutralizing antibody responses to infection and vaccination, and testing of potential novel therapeutics
Overview. Human cytomegalovirus (HCMV) establishes lifelong infections of the host with >60% infected across the globe. In healthy children and adults HCMV produces mild symptoms like influenza or mononucleosis. Read more
Bioinformatics
About us. We aim to develop strategies for pandemic preparedness to combat viral infections. Read more
MSc by Research: Regulation of T cell function by SIK3 in viral infection
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
MSc by Research: Identification of a serum-transferrable factor in helminth infections that prevents respiratory viral infection
In the developing world, parasitic helminths infect a large proportion of the population – up to 1 billion people are infected with soil-transmitted helminth (STH) infections worldwide. Read more
PhD in Chemistry: Medicinal Chemistry of Nucleotide Analogues
Nucleoside analogues (NAs) are an important class of antiviral and anticancer agents commonly used in the therapy of many different viral infections and cancer conditions. Read more
Self funded BMS Project: Tissue-specific roles of human endogenous retroviruses in urothelial carcinoma
Applications accepted for PhD Only. Human endogenous retroviruses (HERVs) are the remnants of retroviral infections in our evolutionary past that contribute 8% of our genome. Read more
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