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We have 23 apoptosis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
apoptosis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 23 apoptosis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage. Read more
Understanding apoptotic heterogeneity in cell populations
Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more
Is there a Role for Activated Akt in Palatogenesis?
Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more
Modulation of the Hippo signalling pathway to enhance cardiac regenerative capacity
Common heart diseases such as heart failure (HF) and coronary heart disease (CHD) are characterized by cardiomyocyte loss due to necrosis and apoptosis. Read more
The Survivin Interactome in Health and Disease
Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Identification of the role of small nucleolar RNAs in cartilage ageing
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
To reduce health inequities and improve the lives of older people we need to understand the ageing process at the molecular level. Read more
Cancer: Inhibiting cell metabolism to enhance tumour cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Dissecting mechanism of drug responses to novel anti-cancer therapies
Repurposing drug screens with compounds that have already gained FDA approval can accelerate the identification of new therapies to treat an illness and in the cancer setting extend life or provide compassionate care. Read more
Countering the proteinase-activated receptor 1 (PAR-1) pro-tumour phenotype using a novel nanotherapeutic approach
Proteinase-activated receptor 1 (PAR1) is a G-protein coupled receptor (GPCR) expressed on a number of cell types, and is activated by serine proteases such as thrombin, plasmin and activated protein C. Read more
Impact of Inflammatory Signals on the Regenerative, Anti-inflammatory and Immunomodulatory Potential of Human Mesenchymal Stem Cells and their Secretome
Adult multipotent stem cells can be easily isolated from a variety of adult human tissues and organs including bone marrow and adipose tissue. Read more
Investigating the role of Golga3 cleavage during SARS-CoV-2 infection
SARS-CoV-2 is the causative agent of the COVID-19 pandemic, responsible for >600 million infections and over six and a half million deaths worldwide by September 2022. Read more
The effects of Interleukin-1 primed mesenchymal stem cells on hypoxic-ischemic brain damage
Hypoxic-ischemic brain damage is one of the main causes of death and neurological disability after stroke worldwide. Read more
Understanding the mechanisms of metabolic reprogramming in cancer: towards novel therapies
In this project, you will examine whether drug-resistant and drug-sensitive cancer cells display distinct metabolic features and aim to do a series of laboratory experiments to investigate the ability of probes, or drugs, to starve cancer cells of glucose. Read more
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