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apoptosis PhD Projects, Programmes & Scholarships
We have 36 apoptosis PhD Projects, Programmes & Scholarships
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Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage. Read more
Understanding apoptotic heterogeneity in cell populations
Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more
Is there a Role for Activated Akt in Palatogenesis?
Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more
Viral regulation of host cell DNA damage response pathways
Human adenoviruses are small non-enveloped viruses and possess a linear, double-stranded DNA genome. Adenovirus has long been used as a tool to dissect the molecular basis of key biological processes such as growth, differentiation and death. Read more
Evaluation of combination therapies targeting DNA damage repair signalling pathways in acute myeloid leukaemia
Acute myeloid leukaemia (AML) is an aggressive cancer affecting mostly adult and elderly patients. It has a very poor 5-year survival of <20% in the UK. Read more
Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Modulation of the Hippo signalling pathway to enhance cardiac regenerative capacity
Common heart diseases such as heart failure (HF) and coronary heart disease (CHD) are characterized by cardiomyocyte loss due to necrosis and apoptosis. Read more
Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting.
Research Group:
Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more
Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins
Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more
Universal genome editing strategies for ataxia telangiectasia
Ataxia telangiectasia (A-T) is a severe autosomal recessive genetic disease caused by mutations in the ATM gene, which lead to cerebellar degeneration, cancer susceptibility and immunodeficiency. Read more
Anticancer potentials of isothiocyanates, diterpenoids, and their molecular mechanisms of interactions (BAOY_U22CPRTFMH)
High consumption of cruciferous vegetables can reduce the risk of cancer. Read more
Investigate the novel therapeutic potential for treating heart failure in diabetes.
Heart failure is the most common cause of mortality in diabetes patients, but current diabetes therapies have a limited impact on the incidence of heart failure in diabetic populations. Read more
Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders
Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more
PhD in Vision Sciences: Evaluating functional outcomes of novel therapies for mitochondrial optic neuropathy using ultra-high resolution multi-electrode array
Mitochondrial optic neuropathies result in blindness and are currently untreatable. They arise as a consequence of genetic mutations in either mitochondrial or nuclear DNA and share the common characteristic of primarily affecting retinal ganglion cell (RGC) survival. Read more
The anti-cancer potential and pharmacological characterisation of Frankincense resin
Interviews will be held on. End of June / early July 2022. The candidate must be able to register by 19th September 2022. Description. Read more