To determine the role of PGD2/CRTh2 axis on non-classical monocytes in asthma
Prof C Brightling, Dr A Wright
Applications accepted all year round
PGD2 stimulation of non-classical monocytes is active in asthma and promotes T2-dependent memory/effector T cell responses. The Prostaglandin D2 / prostaglandin D2 receptor (also known as CRTh2) axis plays an important role in allergic and Type 2 (T2)-mediated moderate to severe asthma [1-3].
Improving the design of medical devices used by asthmatic children
Dr A Marzo, Prof J Wild
15 January 2019
Asthma is a chronic disease that affects 5.4M sufferers in the UK alone. Control of the disease can be achieved by administrating drugs (bronchodilators) using pressurised Metered Dose inhalers, often enhanced by the combined use of asthma spacer devices.
Investigating inflammasome regulation in human myeloid cells
Centre for Experimental Medicine
Dr R Coll, Prof P Moynagh
20 January 2019
Inflammasomes are protein complexes that control inflammation in both infection and sterile injury. Aberrant inflammasome activation is a driver of many diseases including.
Future Climate: Future Pollen and Spores
Dr F Pope
21 January 2019
Globally, atmospheric CO2 concentrations are rising because of anthropogenic activity. They will continue to rise in the coming century.