Background. Immune checkpoint inhibitors (CPIs) such as BLOCKING antibodies targeting CTLA4 (e.g. ipilimumab) have revolutionised the treatment of metastatic cancers by offering long-term remission, by boosting the immune response. Read more
Glycans are sugar-based molecules which play an important role in biological processes ranging from cell-cell communication to energy metabolism. Read more
Type 1 diabetes (T1D) results from a breakdown in immune regulation. This leads to expansion of autoreactive B cells as well as CD4+ and CD8+ T cells targeting the insulin-producing beta cells in pancreatic islets where proinflammatory cytokines play a key role in beta cell death. Read more
Institution. Institute of Immunology, LMU Munich, Biomedical Center (BMC). Remuneration group. TV-L E13. Start date. Earliest convenience, contract for 3 years. Read more
Joint Supervisors. Dr Harriet Walter, Department of Genetics, Genomics and Cancer Sciences and Dr Yolanda Markaki, Molecular & Cell Biology, University of Leicester. Read more
A functioning immune system combats threats to health without causing autoimmunity. Gaining the ability to precisely control the immune response would revolutionise treatments for autoimmune conditions, cancer, transplant rejection, and pathogenic infections. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Project outline. It is becoming clear that the duration, frequency, and intensity of T cell/APC interactions, determines the induction of immunological tolerance versus priming. Read more
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