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autophagy PhD Projects, Programmes & Scholarships

We have 15 autophagy PhD Projects, Programmes & Scholarships

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We have 15 autophagy PhD Projects, Programmes & Scholarships

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Astrocytes as regulators of neuronal autophagy in ageing brain

This project is available through the MIBTP programme. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. Read more
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Isolation and characterization of novel microbial natural products that activate autophagy

This project is available through the MIBTP programme. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. Read more
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PhD Studentship - Selective autophagy as novel therapeutic target for neurodegenerative diseases

Overview. Autophagy is a cellular waste disposal pathway mediated by the formation of double-membraned vesicles called autophagosomes, which ultimately fuse with lysosomes where their content is degraded. Read more

Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

TARGETING MITOPHAGY TO REDUCE CHEMOTHERAPY-INDUCED PAIN

"Background. Chemotherapy-induced peripheral neuropathy (CIPN) is the most commonly reported side effect of chemotherapeutic drugs, affecting quality of life in many cancer patients. Read more

MSc by Research: Investigating mitochondrial autophagy mechanisms in Parkinson’s

Our lab has contributed to how two Parkinson’s disease-linked genes encoding the protein kinase, PINK1 and ubiquitin E3 ligase, Parkin, orchestrate a mitochondrial quality control pathway found in nearly every cell type including neurons. Read more

Cell-type dependent pharmacological regulation of cellular mitophagy for therapeutic application in Parkinson’s disease

The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more

Unlocking new drug targets through antibody-targeted protein degradation

Supervisors. Professor Ed Tate (ICL). Dr Paul Hogg (ADCT, White City). Dr Francesca Zammarchi (ADCT, White City). Targeting protein degradation with Proteolysis-Targeting Chimeras (PROTACs) is an area of great current interest in drug discovery. Read more

Institute of Cancer Sciences

 The Institute of Cancer Sciences is part of a national centre of excellence in the fight against cancer. We carry out a programme of world-class science directed at understanding the molecular changes that cause cancer. Read more

Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more

Cell Signaling and Protein Homeostasis

The Dengjel Lab at the Dept. of Biology, University of Fribourg (. www.unifr.ch/bio/en/research/biochemistry/dengjel.html. ) is interested in cellular signal transduction and protein homeostasis. Read more
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