'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Our lab is interested in biological processes that contribute to drug resistance in myeloid leukaemias, with particular focus on leukaemic stem cells (LSCs). Read more
Autophagy is a lysosomal degradation pathway that is activated upon stress to facilitate clearance of damaged/toxic intracellular contents and recycle essential building blocks to sustain cell survival. Read more
The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself). Read more
TRIM21 is the cytosolic E3 ligase and antibody receptor responsible for intracellular antibody immunity. Unlike other ubiquitin ligases, TRIM21 doesn’t have a defined substrate but is directed towards its targets by antibodies. Read more
The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more
The selective degradation of the endoplasmic reticulum via autophagy, also known as ERphagy, is a fundamental cellular process that has been observed under different stresses and stimuli. Read more
Our ability to fight infections relies not on the capacity of our professional immune system to defend our body but also on the skills of individual cells to defend themselves. Read more
Parkinson’s disease (PD) is the second most common neurological disease in the world. Current PD therapies and medical interventions are limited to addressing the symptoms of this disease. Read more
The MRC Protein Phosphorylation and Ubiquitylation Unit is a world-famous centre for the study of cell signaling and how disruption to signaling pathways causes human disease. Read more
There is great need for improved understanding of the mechanistic biology underlying Parkinson’s disease. Such knowledge will help with development of new drugs that slow or even halt the progression of the disease. Read more
Cancer heterogeneity reduces the effectiveness of many cancer therapies. Therefore, the most promising treatments are those that inhibit several signalling pathways crucial for cancer survival. Read more
The emerging role of biomolecular condensates formed through a liquid-liquid phase separation process inside biological cells is driving a paradigm change in our understanding of cellular organisation. Read more
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