Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Detecting bacterial infection in children is very challenging, particularly in previously well children presenting to the Emergency department (ED) with fever as well as in children with chronic illnesses, such as those with cystic fibrosis (CF). Read more
Project Overview. The World Health Organisation (WHO) predicts antimicrobial resistant (AMR) infections will be the leading cause of death globally by 2050. Read more
Bacterial pathogens respond rapidly to environmental change, in ways that can influence their growth, virulence, antimicrobial resistance and, therefore, infection outcomes. Read more
CONTEXT. Overview of the project. Patients with diabetes have a high risk of a foot ulcer or foot infection. These often re-occur and become chronic. Read more
Project Overview. The emergence of bacterial strains with resistance to multiple classes of antibiotics has led to renewed interest in the antimicrobial properties of metals including silver. Read more
Wider context. Climate change caused by the release of greenhouse gases from fossil fuels and through change of land use threatens life on our planet. Read more
Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more
The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more
Plasmids are extrachromosomal elements in bacteria that confer virulence and resistance against antimicrobials. In the host adapted pathogens, Shigella and Neisseria gonorrhoeae, plasmids have established long evolutionary links with the bacterial species. Read more
Antibiotic resistance (AbR) in bacteria has become a global health emergency. Just in 2019 alone, AbR has caused 1.27 million deaths and was associated indirectly with other 4.95 million deaths1. Read more
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