Imperial College London Featured PhD Programmes
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bioinformatic PhD Projects, Programs & Scholarships

We have 33 bioinformatic PhD Projects, Programs & Scholarships

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  Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1
  Dr T Millard, Dr S Banka
Applications accepted all year round

Funding Type

PhD Type

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene.
  Automated annotation of genes in the non-model era (Ref: SF20/APP/JAMES)
  Dr K James
Applications accepted all year round

Funding Type

PhD Type

Genomics and bioinformatics have been traditionally dominated by a handful of “model” study species. Analysis pipelines and bioinformatic software were initially developed with these species in mind, are biased towards these species, and often fail to perform well on other distantly-related genomes.
  Phenotyping placental disease in women with diabetes and chronic hypertension using transcriptomic analysis
  Dr J Myers, Dr E Johnstone
Applications accepted all year round

Funding Type

PhD Type

Placental disease triggers medically-indicated preterm birth in 1 in 6 pregnancies complicated by chronic hypertension and/or diabetes (cardiometabolic disease).
  Using synthetic biology to harness biopharmaceuticals from microorganisms
  Dr F Alberti, Dr C Corre
Application Deadline: 7 June 2020

Funding Type

PhD Type

Most of the bioactive molecules used in agriculture and medicine are made by microorganisms. For instance, penicillin and cephalosporin antibiotics come from fungi and represent together 47% ($19.8 billion) of the global antibiotic market.
  Gene regulation in cancer metastasis
  Dr F Wardle
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Dr. Fiona Wardle (www.kcl.ac.uk/research/profile/wardle-group) in the Randall Centre for Cell and Molecular Biophysics, King’s College London.
  Bacteriophage role in the establishment of preterm infants’ gut microbiota (Ref: SF20/APP/SMITH3)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Survival of very preterm infants has increased over the last 20 years, but late onset sepsis (LOS) and necrotising enterocolitis (NEC) remain a major cause of death and ongoing developmental problems in this population.
  Bioprospecting & biotechnology - mining the Polar microbial metagenome (Ref: SF20/APP/PEARCE2)
  Prof D Pearce
Applications accepted all year round

Funding Type

PhD Type

This project seeks to exploit new and existing Polar microbial metagenomic libraries for bioprospecting and biotechnology. Using a wide range of diverse molecular techniques, we will research the distribution of particularly useful (e.g.
  Digital Pathology – transforming paediatric brain tumour classification through machine learning (Ref: SF20/APP/SCHWALBE)
  Dr E Schwalbe
Applications accepted all year round

Funding Type

PhD Type

Medulloblastoma is the most common central nervous system tumour of childhood. Although advances in treatment have raised survival to ~75%, there remains significant numbers of patients who die of their disease.
  Temperate bacteriophages and Antimicrobial Resistance (AMR) (Ref: SF20/APP/SMITH2)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Bacterial genomes are studded with prophage regions, some that can be stimulated to produce active phages that horizontally transfer their genomes between related bacterial species.
  The role of bacteriophages in Pseudomonas aeruginosa infection in Chronic Respiratory disease. (Ref: SF20/APP/SMITH1)
  Dr D Smith
Applications accepted all year round

Funding Type

PhD Type

Pseudomonas aeruginosa is a key opportunistic respiratory pathogen in patients with cystic fibrosis and non-cystic fibrosis bronchiectasis.
  Understanding how immune cells support metastasis by “de-constructing” the tumour microenvironment
  Dr L Ombrato, Prof F Balkwill
Application Deadline: 30 June 2020

Funding Type

PhD Type

Breast cancer is the most common cancer in the UK, affecting 1 in 8 women during the course of their lifetime. Despite advances in the treatment of the primary tumour, metastatic disease remains largely uncurable, highlighting urgent clinical unmet needs.
  RET a novel therapeutic target to treat breast cancer brain metastasis
  Prof L Young, Dr A Hill
Applications accepted all year round

Funding Type

PhD Type

Metastatic disease recurrence occurs in up to 30% of breast cancer patients with approximately 20% of these tumours metastasising to the brain.
  Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
  Dr A Kitmitto, Dr E Cartwright
Applications accepted all year round

Funding Type

PhD Type

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease.
  Proteomic analyses of adhesion signalling in cancer
  Prof M J Humphries
Applications accepted all year round

Funding Type

PhD Type

Why adhesion? Cell surface adhesion receptors play key roles in the control of cell movement, survival, division and differentiation.
  The role mRNA-specific translation during chronological aging
  Prof C M Grant, Prof M Ashe, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Biological ageing can be thought of as a progressive decline in the ability of an organism to survive stress and disease. It is a complex process which is influenced by both genetic and environmental factors.
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