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biosynthesis PhD Projects, Programs & Scholarships

We have 37 biosynthesis PhD Projects, Programs & Scholarships

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  Engineering Actinobacteria to enhance natural product biosynthesis
  Dr H O'Hare
Application Deadline: 6 January 2019
The Actinobacteria are important producers of approved drugs (>$1 billion dollars in 2016) but low yields of most natural products are a significant barrier to drug discovery, development and commercialisation.
  4 Year Wellcome Trust PhD Programme: Characterisation of the Group A Carbohydrate biosynthesis machinery
  Dr H Dorfmueller
Application Deadline: 14 December 2018
The Group A Carbohydrate (GAC) is a virulence factor from the human exclusive pathogen Streptococcus pyogenes, which causes a range of diseases, ranging from mild tonsillitis to severe and life-threatening and lethal diseases, such as toxic shock syndrome.
  Engineering lipoglycopeptide biosynthesis to produce new antibiotics
  Research Group: BBSRC White Rose DTP
  Dr R Seipke, Dr G.R. Hemsworth, Dr M E Webb
Application Deadline: 7 January 2019
There is an urgent need for new antibiotics to combat antimicrobial resistance. Most antibiotics originate from Streptomyces bacteria, however the low hanging fruit from this resource has been picked.
  Condition specific engineering of P. putida for rhamnolipid production
  Dr P Rahman, Dr S Robson, Dr C Angione
Application Deadline: 24 February 2019
Applications are invited for a fully-funded three year PhD studentship to commence in October 2019. The project will focus on. Incorporating non-native pathways and to implement innovative and computational-based metabolic design in Pseudomonas putida including oxidative catabolic pathways for lignin degradation.
  Understanding the mechanisms of epidermal barrier damage and repair using 3D skin equivalent models
  Dr J Connelly
Application Deadline: 11 January 2019
The epidermis of the skin provides an essential barrier between our bodies and the external environment through the formation of a dense cornified layer of cross-linked proteins and lipids at the surface of the skin.
  Structure, Function and Biogenesis of the Mycobacterial Cell Wall
  Prof G Besra
Applications accepted all year round
There has been no significant decrease in worldwide mortality due to tuberculosis (TB) since before the time of Koch; the advent of sanatoria and chemotherapy, which drastically reduced TB in the more developed countries, has had no profound effect on the global problem.
  A hidden biochemical pathway in the chemical pathology of diabetes (HAMILTONCU19SF)
  Dr C Hamilton
Applications accepted all year round
In humans, the cysteine-containing tripeptide glutathione (GSH) is an essential thiol cofactor that maintains an intracellular reducing environment to protect against oxidative stress reactive oxygen species, which cause lipid, protein & DNA damage.
  (BBSRC DTP) Novel antimicrobial discovery using high-throughput pathway assembly and robotics
  Prof E Takano, Prof A Munro, Prof R Breitling
Application Deadline: 31 January 2019
This is an interdisciplinary research project in Industrial Biotechnology, especially in the emerging area of Synthetic Biology applied to antimicrobial resistance.
  MRC DiMeN Doctoral Training Partnership: Understanding the molecular pathophysiology of stress on the developing and adult brain
  Dr N Krone, Dr V T Cunliffe
Application Deadline: 21 January 2019
Stress is associated with significant morbidity including depression and anxiety. Activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to synthesis of cortisol, which is a key mediator of the pathology of chronic stress.
  Understanding the genetic control of composition and spatial distribution of the defence compounds glucosinolates in rapeseed plants.
  Prof Ian Bancroft, Dr K Redeker
Application Deadline: 7 January 2019
Glucosinolates are a group of compounds that have a role in defending plants. against pests and diseases. However, they reduce the nutritional value of food.
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