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brain tumour PhD Projects, Programmes & Scholarships
We have 32 brain tumour PhD Projects, Programmes & Scholarships
New Drugs for Brain Tumours: Defining the Physicochemical Parameters for Optimal Imidazotetrazine (Temozolomide) Derivative Prodrug Activation Kinetics
Research Group:
Medicines Development and Pharmaceutical Sciences
The imidazotetrazine ring system that forms the core of the anticancer drug temozolomide is a fascinating prodrug delivery device. Read more
Deconvoluting the spatial multi-omic landscape of high-grade glioma to target post-surgical residual disease
Background. High-grade gliomas are the most common cancers arising within the brain and contribute to ~190,000 brain tumour related deaths/year globally. Read more
Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance
Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more
Evaluation of Tripterygium wilfordii derived compounds as novel treatments for medulloblastoma.
Medulloblastoma is the most common paediatric malignant brain tumour, accounting for 20% of childhood brain tumours cases per annum in the United Kingdom alone, with approximately one-third of patients dying from the disease worldwide. Read more
Disruption of the Connectome in Glioblastomas
The invasive behaviour of glioblastomas (the commonest, most malignant primary brain tumour) means that local treatments won’t cure these tumours, and this diffuse invasion means that there is a disruption of normal cognitive structures. Read more
Computational modelling of the human blood-brain barrier to tackle multidrug resistance and neurodegenerative disorders (molecular dynamics/deep generative learning/AI)
By 2050 the number of people living with neurodegenerative disorders are set to double. Alzheimer’s disease in particular is set to become a public health emergency. Read more
Understanding how to target the T cell compartment within related brain tumours
T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more
Investigating local invasion in primary and secondary brain tumours
Brain tumours are highly invasive and carry a poor prognosis. Secondary brain tumours or brain metastases (BM) are the most common tumours found in the brain affecting up to one third of patients with solid organ cancer. Read more
New Drugs for Brain Tumours: A Locoregional Implant Brain Tumours
Research Group:
Medicines Development and Pharmaceutical Sciences
Next-generation temozolomide derivatives for the treatment of high-grade glioma have been developed at the University of Bradford. Read more
MAC4ME: Macrophage metabolism and ageing in the brain metastatic microenvironment of neuroblastoma in response to therapy using 3D in vitro models
Cancer and the long-term toxicities sustained from treatment remain a public health issue for adult and paediatric patients. The spread of tumour cells is believed to account for up to 90% of cancer-related morbidities. Read more
Triple Negative Breast cancer control of the immune tumour microenvironment in metastasis
Metastasis, the spread of cancer to secondary organs, accounts for approximately 90% of cancer-related deaths mainly due to resistance to conventional treatments and organ failure. Read more
Develop synthetic extracellular matrix for engineering defined 3D human neural tissue
Commercial partner: PeptiMatrix. Extracellular matrix (ECM) constitutes around 20% of the adult brain volume and plays an important role in brain function and disease. Read more
Mapping cellular trajectories in the senescence spectrum
Research Group:
Narita Group
Overview. Professor Masashi Narita wishes to recruit a student to work on the project entitled. "Mapping cellular trajectories in the senescence spectrum". Read more
Multi-modal spatial data integration to predict breast cancer treatment response
Research Group:
Ali Group
Overview. Dr Raza Ali wishes to recruit a student to work on the project entitled. "Multi-modal spatial data integration to predict breast cancer treatment response". Read more
Investigating the low-to-high grade glioma transition using spatial multi-omics
Research Group:
Hannon Group
Overview. Prof Greg Hannon, Dr Richard Mair and Dr Dario Bressan wish to recruit a student to work on the project entitled. "Investigating the low-to-high grade glioma transition using spatial multi-omics". Read more