A universal characteristic of all cancer cells is the reprogramming of cell metabolism to provide the energy and building blocks necessary to support proliferation and survival.
High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer and accounts for 70% of all ovarian cancer deaths.
Gastric cancer (GC) is the fourth most common cancer globally and 7th in incidence in Australia. It has a poor survival rate which can be attributed to the advanced stage at diagnosis in most patients.
P53 is the most mutated gene in human cancer, affecting about half the cases of human cancer. We have recently identified novel regulators of mutant p53 using sophisticated loss of function whole genome high through put screen (image 1).
A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
Triple negative breast cancers are a poor prognosis breast cancer with limited therapeutic options as they do not express estrogen receptors, progesterone receptors or Her2.
