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We have 61 cancer therapeutics PhD Projects, Programmes & Scholarships

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cancer therapeutics PhD Projects, Programmes & Scholarships

We have 61 cancer therapeutics PhD Projects, Programmes & Scholarships

4D printed Biomaterials in cancer therapeutics

According to WHO, cancer is the second leading cause of death worldwide, with nearly 1 in 6 deaths been due to cancer. The principal modes of cancer management are surgery, radiotherapy, chemotherapy and pharmaceutical agents. Read more

A bifunctional prodrug to overcome acquired oxaliplatin drug resistance in colorectal cancer

  Research Group: Institute of Cancer Therapeutics
This is one of two new fully funded PhD studentships in the Institute of Cancer Therapeutics Doctoral Training Centre (ICT-DTC) at the University of Bradford. Read more

Polysialyltransferases as a target in metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer

  Research Group: Institute of Cancer Therapeutics
Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an uncontrolled fashion. Read more

Investigation of novel PARP7-targeting agents for the treatment of cancer

PARP7, an ADP-ribosyltransferase, modulates protein function by adding an ADP-ribose moiety to target proteins. It is involved in many physiological and pathophysiological processes such as neural development, maintenance of stem cells, immunity, xenobiotic metabolism, immunity and cancers. Read more
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The Influence of Omega-3 Polyunsaturated Fatty Acids on the Development and Prevention of Skin Cancers (Ref: AACME-24-018)

Background. biomedical application of fish oil-derived omega-3 fatty acids. Dietary intake of omega-3 polyunsaturated fatty acids from fish oils has been shown to have various beneficial effects against inflammation and inflammatory diseases, as well as anti-tumour effects. Read more

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Computational and machine learning driven development of new polysialyltransferase (ST8SiaII) inhibitors against metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid (polySia) is a carbohydrate polymer important for embryonic development. PolySia is absent in healthy adult tissues whereas overexpressed in several tumours. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Synthesis of anticancer alkaloids

  Research Group: Chemistry and Biosciences
Luotonin A is a natural occurring plant alkaloid bearing polycyclic quinazolinone. It has shown inhibitory effect towards topoisomerase I (TP1), an enzyme responsible for antibiotic and anticancer. Read more

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