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cartilage PhD Projects, Programmes & Scholarships

We have 30 cartilage PhD Projects, Programmes & Scholarships

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We have 30 cartilage PhD Projects, Programmes & Scholarships

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Regulation of the tissue degradation in osteoarthritis

  Research Group: Biomedical Research Group
Research Group. Biomedical Research Group. Proposed supervisory team. Dr Joseph Bird. Dr Peter Coussons. Dr Felicity Savage. Theme. Read more

Plasminogen-activator inhibitor (PAI-1) in the musculoskeletal system: a key serine proteinase inhibitor regulating joint homeostasis

This PhD studentship will use in vitro, ex vivo and in vivo models to investigate the role of an important serine proteinase inhibitor (serpin) in the musculoskeletal system, leading to a better understanding of disease and opening new pathways to therapeutic intervention. Read more

Suppressing mechanoflammation in osteoarthritis by targeting apoptosis-signal regulating kinase-1

The cellular basis of osteoarthritis (OA) remains incompletely understood. The most important aetiological factor in OA development is mechanical stress, so how the tissues of the joint respond to mechanical stress is likely to be important in disease. Read more

Identify new drug targets for treating OA by inducing autophagy (NDORMS 2023/2)

Drugs targeting biological drivers of aging face unique translational challenges. In this DPhil, a translational strategy targeting an age-associated disease will be leveraged to advance an immediately clinically relevant intervention. Read more

PhD Candidates Biomedical Data Sciences and Rheumatology

The department of Biomedical Data Sciences and the department of Rheumatology of LUMC are looking for two ambitious PhD students to join a nationwide consortium aiming to develop treatment for osteoarthritis. Read more

Solid-state NMR approaches to deliver new insights into the extracellular matrix

  Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)
The extracellular matrix (ECM) contains important chemical and mechanical cues to shape and alter cell behaviour. However, there are limited tools for analysing the structures and structural interactions present at the atomic length scale within the intact ECM. Read more

MRC DiMeN Doctoral Training Partnership: CRISPR-based genome and epigenome perturbation in stem cells to understand and reverse osteoarthritis risk

Osteoarthritis affects 8.5million UK adults and is defined by cartilage breakdown, pain, and disability. Osteoarthritis is caused by multiple different factors, with genetics contributing ~50% to an individual’s lifetime risk of developing the disease. Read more

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