Tissue formation critically depends on the appropriate assignment of specialised cell fates and behaviours. The traditional perspective of these competitive decisions is that cells first perceive extrinsic signalling cues, decide their fate and then act appropriately (i.e.
Biomedical Sciences Research Centre
Dr M Bischoff
7 January 2019
Background. To shape tissues and organs, cells undergo different behaviours, such as cell migration and shape change. Many morphogenetic processes rely on collective cell migration, where cells move coordinately as a group (Scarpa and Mayor, 2016).
EML4 is a poorly characterised microtubule-associated protein . The purpose of this cell biology-focused PhD project is to explore the molecular mechanisms through which EML4 regulates microtubule dynamics and cell migration.
The self-renewal and differentiation of stem cells is controlled by signals derived from the microenvironment or “niche”. The paired hematopoietic organs of the Drosophila genetic model organism are a well-characterized system in which the regulation of stem cell behaviour within a niche can be genetically dissected.
We have an exciting opportunity for a student who wishes to work at the interface of cancer medicine and mathematics. This cross-disciplinary project is part of a thriving collaboration between the Biomathematics Group (P Thomas) and the MRC London Institute of Medical Sciences (LMS; A Barr) at Imperial College London.