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cell PhD Projects, Programmes & Scholarships
We have 798 cell PhD Projects, Programmes & Scholarships
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Live cell imaging of epithelial cancer cell proliferation for therapy
The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2023/24. Read more
Understanding apoptotic heterogeneity in cell populations
Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more
Investigate the role of Lamellipodin and the NHS protein family, key regulators of the actin cytoskeleton, in cancer cell migration using CRISPR-Cas9, microfluidics, and advanced live cell imaging.
Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. Metastasis is the primary cause of cancer related deaths. Read more
How one archaeal cell becomes two
The origin of eukaryotic cell organisation remains one of the great unknowns in the history of life on earth. However, there is growing consensus that eukaryotes likely arose from a merger between an Asgard archaeal cell and an alpha-proteobacterial cell over a billion years ago. Read more
PhD in Infection, Immunity, Antimicrobial Resistance & Repair - Clonal aging of anti-viral T cells impacts protective immunity
SUMMARY. The induction and persistence of effective antigen(Ag)-specific memory T-cell responses is required to bestow long-term protection against infectious diseases, and hence is critical to vaccine development. Read more
Machine learning and statistical modelling of trans-omic networks in controlling cell identity, cell-fate decisions, and cancers
The advances in mass spectrometry-based proteomics and phosphoproteomics, and next-generation sequencing-based transcriptomics and epigenomics create the opportunity to study cell identity, cell-fate decisions, and complex diseases such as cancers at a system level. Read more
Dynamic cell fate decisions: linking mechanical signals and protein expression dynamics in the developing eye to understand human developmental disorders
Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation. Read more
The role of extracellular vesicles in lung epithelial cell communication in health and disease
It is estimated that more than 1 bn people suffer from acute and chronic lung problems resulting in millions of deaths every year. Read more
Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer
Research Group:
Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more
Cancer: Inhibiting cell metabolism to enhance tumour cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Investigate the molecular mechanism controlling FEME (Fast Endophilin Mediated Endocytosis) in directed cancer cell migration using CRISPR, biochemistry, and advanced microscopy methods.
Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. Metastasis is the primary cause of cancer related deaths. Read more
The functions of the YAP/TAZ oncoproteins in cell cycle control and tumour progression.
Background. Squamous cell carcinomas (SCCs) - cancers arising from multi-layered epithelia such as the skin epidermis or the oral mucosa - are the most diagnosed cancers in the UK and world-wide. Read more
PhD in Infection, Immunity, Antimicrobial Resistance & Repair - Understanding the interactions of Dengue virus with the immune system and its impact on disease
SUMMARY. Natural killer (NK) cells are critical for killing virus-infected cells but can also cause immunopathology. This project investigates whether Dengue virus manipulates NK ligands to prevent NK cell killing and whether NK cells contribute to dengue pathogenesis. Read more
Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy
It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more
Defining a molecular platform for the development of cell selective and cell permeable antibody conjugates
Keywords. Biologics; Drug Delivery; Chemical Biology; Bioanalysis. We are seeking a PhD student to develop next-generation antibody conjugates for cell specific targeting. Read more
