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  (BBSRC DTP) Morphological control of cell fate, behaviour and function
  Dr S Herbert, Prof N Papalopulu, Dr M Baron
Application Deadline: 31 January 2019
Tissue formation critically depends on the appropriate assignment of specialised cell fates and behaviours. The traditional perspective of these competitive decisions is that cells first perceive extrinsic signalling cues, decide their fate and then act appropriately (i.e.
  Mechanisms of microtubule organization by cell-cell adhesion in epithelial cells.
  Dr N Bulgakova
Applications accepted all year round
The correct organization of the microtubule cytoskeleton is critical for the survival and normal function of cells in a multicellular organism.
  Hematopoietic Stem Cell Genetics: Using single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
  Prof Claus Nerlov, Dr P Vyas
Application Deadline: 26 July 2019
Using single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
  The effect of polysialyltransferase modulation on tumour cell migration
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr R Falconer
Applications accepted all year round
One of the main reasons for failure of cancer therapy today is an inability to control tumour dissemination, with secondary tumour deposits the cause of morbidity.
  Profiling stem cell epigenetic transitions within the Drosophila hematopoietic stem cell niche
  Dr P Badenhorst, Prof C Bonifer
Applications accepted all year round
The self-renewal and differentiation of stem cells is controlled by signals derived from the microenvironment or “niche”. The paired hematopoietic organs of the Drosophila genetic model organism are a well-characterized system in which the regulation of stem cell behaviour within a niche can be genetically dissected.
  Stochastic modelling of cell cycle control in cancer
  Dr P Thomas, Dr A Barr
Application Deadline: 31 January 2019
We have an exciting opportunity for a student who wishes to work at the interface of cancer medicine and mathematics. This cross-disciplinary project is part of a thriving collaboration between the Biomathematics Group (P Thomas) and the MRC London Institute of Medical Sciences (LMS; A Barr) at Imperial College London.
  Haematopoietic Stem Cell Biology: Understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies
  Dr A Mead, Dr S Thongjuea, Dr B Psalia
Application Deadline: 26 July 2019
Understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies.
  ’Mechano-culture’ of stem cells for tissue engineering and regenerative medicine
  Dr JR Henstock
Applications accepted all year round
OVERVIEW. The core objective of the PhD is to develop a new pneumatic (hydrostatic) pressure bioreactor for manufacturing mesenchymal stem cells.
  Targeting The Thymus To Improve Immune Recovery Following Stem Cell Transplantation For Cancer Treatment
  Prof G Anderson, Dr W Jenkinson
Applications accepted all year round
Background. The treatment of cancer frequently requires the transplantation of bone marrow to regenerate the immune system that is damaged following ablative therapy.
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