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cell cycle PhD Projects, Programmes & Scholarships

We have 50 cell cycle PhD Projects, Programmes & Scholarships

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We have 50 cell cycle PhD Projects, Programmes & Scholarships

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Cell/extracellular matrix interaction during cell cycle progression: a novel role in controlling nucleotide metabolism?

The deregulation of cell cycle progression is a common feature of cancer formation and progression. Cell/extracellular matrix (ECM) interaction is widely known to support the progression of the cells through the cell cycle. Read more

Investigating the cell biology of Neoparamoeba perurans, a causative agent of Amoebic Gill Disease, and its endosymbiont kinetoplastid, Perkinsela.

Amoebic gill disease (AGD), caused by the opportunistic amoebozoan parasite Neoparamoeba perurans, is a major disease in salmonid aquaculture [1-3] and there is an urgent need to mitigate the impact parasitic infections have on both fish welfare and sustainable growth in the sector. Read more

Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy. Read more

MSc by Research: Does CDK1 regulate NICD turnover in a cell cycle dependant manner in Drosophila Melanogaster?

Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life, including cell fate specification within progenitors. . Read more

Uncovering the molecular mechanisms underlying spinal cord regeneration

About 1200 people a year are left paralysed in the UK due to a Spinal Cord Injury (or SCI). This is because injuries involving the central nervous system (CNS) have very poor capacities to regenerate, thus resulting in a permanent loss of function. Read more

Regulation of nuclear actin in human cancer

Actin is a cytoskeletal protein that plays essential roles in many cellular processes, such as adhesion, intracellular trafficking, membrane dynamics and motility. Read more

Cancer biology: identification of new treatment options for EML4-ALK driven lung cancer through understanding mechanisms of cell division and migration.

Lung cancer is the largest cause of cancer-related deaths in the UK and worldwide. While little progress has been made in long-term survival rates, we now have a good understanding of the genetic drivers raising the prospect of earlier diagnosis and more effective treatments. Read more

Understanding coordination of DNA replication initiation in the African trypanosome

DNA replication is a central cellular reaction, necessary for genome transmission and the propagation of life. To date, structural and mechanistic studies on DNA replication have focused mainly on a small number of eukaryotes, revealing conserved machinery and reactions. Read more

Viral regulation of host cell DNA damage response pathways

Human adenoviruses are small non-enveloped viruses and possess a linear, double-stranded DNA genome. Adenovirus has long been used as a tool to dissect the molecular basis of key biological processes such as growth, differentiation and death. Read more

A role for cholesterol metabolism in neurodevelopmental disorder

Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more

Investigating novel molecular regulators of the brown adipocyte programme

Brown adipose tissue is an enigmatic tissue that plays an important role in energy metabolism. The increasing prevalence of obesity-related disorders has led to a growing need for therapeutic strategies to reverse diet-induced weight gain. Read more

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