(BBSRC DTP) Morphological control of cell fate, behaviour and function
Dr S Herbert, Prof N Papalopulu, Dr M Baron
31 January 2019
Tissue formation critically depends on the appropriate assignment of specialised cell fates and behaviours. The traditional perspective of these competitive decisions is that cells first perceive extrinsic signalling cues, decide their fate and then act appropriately (i.e.
Cleavage of receptor protein tyrosine phosphatases: mechanisms and consequences
Dr D Cunningham, Dr M Tomlinson
6 January 2019
This project aims to establish a new paradigm in cell signalling by showing how cell surface-anchored phosphatases can be converted into distinct cytoplasmic phosphatases by a cleavage event, thus effectively doubling a cell’s phosphatase repertoire.