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cell therapy PhD Projects, Programmes & Scholarships

We have 144 cell therapy PhD Projects, Programmes & Scholarships

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We have 144 cell therapy PhD Projects, Programmes & Scholarships

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Improving the viability of transplanted kidneys using cell therapy

Transplantation is the gold-standard treatment for end stage kidney disease but there is a shortage of suitable organs. To increase the donor pool, there has been increasing use of so-called ‘marginal’ kidneys from ‘donation after circulatory death’ (DCD) donors which are typically elderly donors with comorbidities. Read more
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EASTBIO A novel synthetic biology approach towards anti-bacterial cell therapy

  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
Project Description. With the rising threat posed by antimicrobial resistance and the slow pace at which new antibiotics are being developed, never has the need for new anti-bacterial treatment strategies been more pressing. Read more
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EASTBIO: Optimisation of Allogeneic GMP Grade Mesenchymal Stromal Cells To Promote The Long Term Engraftment And Function Of Islets

This PhD proposal offers the unique opportunity of working with leading clinician scientists in the field of Type 1 diabetes and cell therapy experts at the Scottish National Blood Transfusion Service with a proven track-record of taking cell therapies to the clinic. Read more

Tissue tropism in PD-1 therapy

Programmed cell death protein 1 (PD1) is an immune checkpoint receptor expressed on immature thymocytes as well as peripheral CD4+ and CD8+ T cells, Natural Killer T (NKT) cells, B cells, monocytes and subsets of dendritic cells upon activation. Read more

Self funded BMS Project: Understanding the population dynamics of haematopoietic stem cells during gene therapy for sickle cell disease

Applications accepted for PhD Only. Background. This project builds on the recent discovery that whole genome sequencing approaches in blood stem and progenitor cells can be used to estimate the number of actively contributing blood stem cells in humans (Lee-Six et al., Nature 2018). Read more

Development of biodegradable polymeric systems for drug delivery & tissue engineering applications (SAEEDA_U23SF)

The goal of this project is to create a new line of biodegradable polymeric delivery systems with built-in cell adhesion moieties for formulation of therapeutic agent drug delivery as well as tissue engineering and regenerative medicine applications. Read more

Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting. (Ref SHLS20065)

  Research Group: Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more

Advanced 3D models for Cancer Research

Radiotherapy and many chemotherapies kill cells by damaging DNA. The efficiency of these DNA damaging agents differs between tumour types and individual patients. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more
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Stemness and maintenance of CD4+ regulatory T cell (Treg) responses in homeostasis, inflammation and ageing

CD4+ Regulatory T (Treg) cells are rare immune cells with powerful immunoregulatory functions. Loss of Treg cells results in lethal inflammation, while defects in their function are associated with autoimmunity and allergy. Read more

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