Skeletal muscle development is a complex process and a number of regulatory factors for the different steps involved in stem cell activation and proliferation through to multinucleated, post-mitotic cells have been identified.
Developments from academic and biotech sectors have driven gene and stem cell therapy to the clinical setting, with data demonstrating an encouraging long term safety profile and durable correction of several inherited genetic blood disorders such as ADA-SCID (Strimvelis) and X-CGD (OTL-102).
Dilated Cardiomyopathy (DCM) is a common and serious disease, which imposes a significant welfare burden in dogs. DCM is particularly well characterise in Dobermans where a 58.8% cumulative prevalence has been identified in European lines.
Overall aim of the PhD project is to develop novel T-cell immunotherapy for paediatric high grade glioma. Brain tumours are the major cause of cancer-related death in children, overtaking the other paediatric cancers including leukaemias and other solid tumours.
Background. A hallmark of cancer is aberrant cell cycle control leading to pathological cell proliferation. Cell cycle progression is controlled by key kinases, such as cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs).
Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.