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We have 150 cell therapy PhD Projects, Programmes & Scholarships

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cell therapy PhD Projects, Programmes & Scholarships

We have 150 cell therapy PhD Projects, Programmes & Scholarships

Precision Medicine DTP - Integrative single-cell transcriptomic to identify novel mediator of human blood progenitor proliferation

  Research Group: MRC Centre for Regenerative Medicine
Background. Hematopoietic stem cells (HSCs) are the most widely used cells for cell therapy because of their unique ability to reconstitute the entire blood and immune system upon transplantation. Read more

MRC DiMeN Doctoral Training Partnership: Enabling safe and efficient generation of stem cell-based therapies

Cell replacement therapies aim to heal diseased or injured tissues by replacing missing or defective cells. Human pluripotent stem cells (hPSCs) represent an essential pillar of such efforts due to their ability to proliferate extensively and to differentiate into any cell type. Read more

Selection and characterisation of immortalised human beta cells for gene therapy of diabetes

  Research Group: Biomedical Sciences
The study of beta-cell function is limited by supply of viable human islets. Initial studies of insulin secretion involved microdissection of collagenase isolated rodent islets, but translatability to humans has been questioned. Read more

‘Computational Biology: Single-cell Signalling Analysis of Stem Cell Polarisation in Cancer’

About the Project. Colorectal cancer (CRC) afflicts >900,000 people/year worldwide. CRC tumours are complex heterocellular systems comprising mutated cancer cells, stromal fibroblasts, and multiple immune cells across the tumour microenvironment (TME). Read more

Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more

Screening of CAR-T cell therapies using 3D microfluidic tumour models

This project focusses on advancing chimeric antigen receptor (CAR-T) cell therapy as a revolutionary treatment for cancer. While CAR-T cells have shown exceptional success against blood cancers there is a need to overcome challenges such as side effects and testing complexities. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

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