Stochastic modelling of cell cycle control in cancer
Dr P Thomas, Dr A Barr
31 January 2019
We have an exciting opportunity for a student who wishes to work at the interface of cancer medicine and mathematics. This cross-disciplinary project is part of a thriving collaboration between the Biomathematics Group (P Thomas) and the MRC London Institute of Medical Sciences (LMS; A Barr) at Imperial College London.
Investigating phosphorylation-dephosphorylation dynamics during the cell cycle.
Dr A Saurin
Applications accepted all year round
Protein phosphorylation is a critical post-translational modification needed for most biological responses. Although we have currently identified hundreds of thousands of different phosphorylation sites, we still lack one fundamental piece of information that is common to every single one of those sites.
Development of novel nano-agents to target DNA replication forks and modulate cell cycle and activity
Prof M Hannon, Dr N J Hodges, Prof G Stewart
6 January 2019
We have developed a novel class of metal-based cylinders that bind to DNA Y-shaped junctions. These cylinders show an exciting activity to push rapidly dividing cells into cytostasis (in cell line studies) but we want to further understand the basic cell and molecular biology of these agents in more detail specifically.