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We have 241 cell signalling PhD Projects, Programmes & Scholarships
cell signalling PhD Projects, Programmes & Scholarships
We have 241 cell signalling PhD Projects, Programmes & Scholarships
Pharmacological protection against a bad diet: a Drosophila model
Maintaining metabolic function is key to lifelong health. Changes in metabolism that disrupt cellular energy balance are now considered causative factors for multiple human diseases including diabetes, cancer and neurodegeneration. Read more
(Bicentenary) Unblocking blood vessels: Mechanisms of thrombi extrusion and removal in health and disease
In an era in which cardiovascular micro-occlusive diseases are becoming increasingly common due to lifestyle/environment (atherosclerosis), aging (Alzheimer’s disease/dementia), and medical complications (long COVID), insights into the endogenous mechanisms of thrombi removal and vessel recanalisation could inform new therapeutic strategies to tackle these crippling conditions. Read more
Development of Organelle Targeted Ligands to Delineate GPCR signalling
G protein-coupled receptors (GPCRs) are a large family of integral membrane proteins comprising seven transmembrane α-helical domains that relay… Read more
Development of Organelle Targeted Ligands to Delineate GPCR signalling
G protein-coupled receptors (GPCRs) are a large family of integral membrane proteins comprising seven transmembrane α-helical domains that relay… Read more
Structural and cellular characterisation of Bacillus subtilis chloride channels
Bacterial electrophysiology is an emerging exciting cutting-edge field of physical biology. Membrane potential, the electrical potential difference across the membrane, is known to drive neural signalling, but it is often assumed to be homeostatic in non-excitable cells. Read more
Role of primary cilia in skeletal muscle stem cells and muscle regeneration
Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more
Role of stem cell-derived extracellular vesicles in immune cell function; clinical development of a new biotherapeutic
Human mesenchymal stem cells (MSCs) are found in adult tissues such as bone marrow and are able to form bone, cartilage and fat tissues. Read more
Signalling complexes and cell wall changes during plant reproduction
We are looking for a student interested in plant developmental, molecular and cell biology to join a vibrant and supportive group of researchers (jointly headed by Lisa Smith, Sam Amsbury and Andrew Fleming), providing an excellent collaborative environment for your PhD at the University of Sheffield. Read more
Deciphering the role of biomechanical cues in embryonic cell fate decisions using human pluripotent stem cells
The structures that make up the human body trunk, such as the spinal cord and the vertebral column are produced during embryonic development by populations of stem cell-like progenitors (known as neuromesodermal progenitors or NMPs), which are located at the posterior of the embryo. Read more
Investigating Neuropeptide Signalling From Synthesis to Survival
Project Overview. Neuropeptides, comprising of short amino acid chains, are potent bioactive molecules with extensive neuromodulatory functions and are predominantly expressed within the central nervous system. Read more
B cell responses during tumour development
The body remains free of infections and disease due to the cascade of actions of the cells and organs of our immune system. During tumour development, tumours induce changes within the local environment and in downstream locations, such as the lymph nodes. Read more
Understanding the beginning of life: the biological role of UBE2Q1 and non-canonical ubiquitination in mouse embryonic cells
Ubiquitination is a fundamental post-translational modification (PTM), which profoundly impacts diverse cellular functions, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune response. . Read more
Investigating the molecular mechanisms of dietary treatments in Angelman syndrome
Angelman syndrome is a severe neurodevelopmental disorder, with symptoms including development delay, speech impairment, intellectual disability, epilepsy, and ataxia (1). Read more
Bowel cancer caused by bacteria
The gut microbiome has a profound effect on health and disease of humans and colorectal cancer (CRC) is one such disease influenced by microorganisms. Read more
EastBio: Investigating how cell size impacts proteome homoeostasis and cellular signaling.
One of the most obvious differences between cells of different type is their size. Even within a given cell type, there are constant variations in size and, of course, a single proliferating cell will double in size every cell cycle. Read more